Anterior thalamic stimulation improves working memory precision
文献类型：期刊论文
| 作者 | Liu, Jiali1,2 ; Yu, Tao3,4; Wu, Jinfeng1,2; Pan, Yali1; Tan, Zheng1,2; Liu, Ruobing1,2; Wang, Xueyuan3,4; Ren, Liankun3,4; Wang, Liang1,2
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| 刊名 | BRAIN STIMULATION
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| 出版日期 | 2021-09-01 |
| 卷号 | 14期号:5页码:1073-1080 |
| ISSN号 | 1935-861X |
| 关键词 | Anterior nucleus of thalamus Electrical stimulation Hippocampus Neural oscillations Working memory precision |
| DOI | 10.1016/j.brs.2021.07.006 |
| 通讯作者 | Wang, Liang(lwang@psych.ac.cn) |
| 英文摘要 | Background: The anterior nucleus of thalamus (ANT) has been suggested as an extended hippocampal system. The circuit of ANT and hippocampus has been widely demonstrated to be associated with memory function. Both lesions to each region and disrupting inter-regional information flow can induce working memory impairment. However, the role of this circuit in working memory precision remains unknown. Objective: To test the role of the hippocampal-anterior thalamic pathway in working memory precision, we delivered intracranially electrical stimulation to the ANT. We hypothesize that ANT stimulation can improve working memory precision. Methods: Presurgical epilepsy patients with depth electrodes in ANT and hippocampus were recruited to perform a color-recall working memory task. Participants were instructed to point out the color they were supposed to recall by clicking a point on the color wheel, while the intracranial EEG data were synchronously recorded. For randomly selected half trials, a bipolar electrical stimulation was delivered to the ANT electrodes. Results: We found that compared to non-stimulation trials, working memory precision judgements were significantly improved for stimulation trials. ANT electrical stimulation significantly increased spectral power of gamma (30-100 Hz) oscillations and decreased interictal epileptiform discharges (IED) in the hippocampus. Moreover, the increased gamma power during the pre-stimulus and retrieval period predicted the improvement of working memory precision judgements. Conclusion: ANT electrical stimulation can improve working memory precision judgements and modulate hippocampal gamma activity, providing direct evidence on the role of the human hippocampalanterior thalamic axis in working memory precision. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 收录类别 | SCI |
| WOS关键词 | MEDIAL TEMPORAL-LOBE ; BRAIN-STIMULATION ; ELECTRICAL-STIMULATION ; GAMMA ; HIPPOCAMPUS ; ATTENTION ; SEQUENCE ; NETWORK ; PERFORMANCE ; PATHWAYS |
| 资助项目 | National Natural Science Foundation of China[31771255] ; National Natural Science Foundation of China[81771395] ; National Natural Science Foundation of China[32020103009] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32010300] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000697707200005 |
| 资助机构 | National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Science ; CAS Interdisciplinary Innovation Team |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40288]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wang, Liang |
| 作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing, Peoples R China 4.Capital Med Univ, Beijing Key Lab Neuromodulat, Comprehens Epilepsy Ctr Beijing, Dept Neurol,Xuanwu Hosp, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiali,Yu, Tao,Wu, Jinfeng,et al. Anterior thalamic stimulation improves working memory precision[J]. BRAIN STIMULATION,2021,14(5):1073-1080. |
| APA | Liu, Jiali.,Yu, Tao.,Wu, Jinfeng.,Pan, Yali.,Tan, Zheng.,...&Wang, Liang.(2021).Anterior thalamic stimulation improves working memory precision.BRAIN STIMULATION,14(5),1073-1080. |
| MLA | Liu, Jiali,et al."Anterior thalamic stimulation improves working memory precision".BRAIN STIMULATION 14.5(2021):1073-1080. |
入库方式： OAI收割
来源：心理研究所
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