Post-traumatic stress disorder is a persistent psychological disorder that occurs for a period of time after an individual has been directly or indirectly exposed to a traumatic event,and this disorder can seriously affect the individual's daily living status and work situation.According to studies,about 1/3 of people with PTSD have the disorder for life,and the suicide rate is 6 times higher than that of the general population.The pathogenesis of the disease is still inconclusive,and the effect of conventional clinical drug therapy is limited and has significant side effects.At the same time,increasing attention has been paid to the importance of neuropeptide Y(NPY)for individuals to cope with stress and recover from traumatic events.In this paper,we explore the relationship between neuropeptide Y and the hypothalamic-pituitary-adrenal axis,Glutamate andγ-aminobutyric acid neurons,locus coeruleus-norepinephrine system,and corticotropin releasing factor,which are closely related to posttraumatic stress disorder,to identify the neural circuit of neuropeptide Y.It may provide a new perspective for the prevention and treatment of PTSD and for the understanding of its developmental mechanisms.

创伤后应激障碍是指个体直接或间接地暴露于创伤性事件后一段时间内出现的持续性精神障碍,这种障碍会严重影响个体日常生活状态和工作情况。根据研究显示,约1/3的创伤后应激障碍患者终生难愈,自杀率是一般人群的6倍。目前其发病机制尚无定论,临床常规药物疗法效果有限而且副作用明显。与此同时,神经肽Y对于个体应对应激、从创伤性事件中恢复的重要性受到越来越多的关注。本文通过探讨神经肽Y与创伤后应激障碍密切相关的下丘脑-垂体-肾上腺轴、谷氨酸和γ-氨基丁酸神经元、蓝斑-去甲肾上腺素系统以及促肾上腺皮质激素释放激素的关系,初步明确神经肽Y作用的神经环路,可以为预防和治疗创伤后应激障碍以及理解其发生发展机制提供一个新视角。

中国科学院心理健康重点实验室开放课题(KLMH2018K03)