中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The role of negative emotions in sex differences in pain sensitivity

文献类型:期刊论文

作者Huijuan, Zhang1,2; Yanzhi, Bi1,2; Xin, Hou1,2; Xuejing, Lu1,2; Yiheng, Tu1,2; Li, Hu1,2
刊名Neuroimage
出版日期2021-11-03
卷号245
通讯作者邮箱biyz@psych.ac.cn (y. bi) ; huli@psych.ac.cn , huli@swu.edu.cn (l. hu)
关键词Pain sensitivity Sex difference Pain-related fear Pain-related anxiety Amygdala subnuclei volumes Magnetic resonance imaging
DOI10.1016/j.neuroimage.2021.118685
产权排序1
文献子类实证研究
英文摘要

Pain perception varies widely among individuals due to the varying degrees of biological, psychological, and social factors. Notably, sex differences in pain sensitivity have been consistently observed in various experimental and clinical investigations. However, the neuropsychological mechanism underlying sex differences in pain sensitivity remains unclear. To address this issue, we quantified pain sensitivity (i.e., pain threshold and tolerance) using the cold pressure test and negative emotions (i.e., pain-related fear, pain-related anxiety, trait anxiety, and depression) using well-established questionnaires and collected magnetic resonance imaging (MRI) data (i.e., high-resolution T1 structural images and resting-state functional images) from 450 healthy subjects. We observed that, as compared to males, females exhibited lower pain threshold and tolerance. Notably, sex differences in pain sensitivity were mediated by pain-related fear and anxiety. Specifically, pain-related fear and anxiety were the complementary mediators of the relationship between sex and pain threshold, and they were the indirect-only mediators of the relationship between sex and pain tolerance. Besides, structural MRI data revealed that the amygdala subnuclei (i.e., the lateral and basal nuclei in the left hemisphere) volumes were the complementary mediators of the relationship between sex and pain-related fear, which further influenced pain sensitivity. Altogether, our results provided a comprehensive picture of how negative emotions (especially pain-related negative emotions) and related brain structures (especially the amygdala) contribute to sex differences in pain sensitivity. These results deepen our understanding of the neuropsychological underpinnings of sex differences in pain sensitivity, which is important to tailor a personalized method for treating pain according to sex and the level of pain-related negative emotions for patients with painful conditions.

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收录类别SCI
语种英语
出版者ELSEVIER
源URL[http://ir.psych.ac.cn/handle/311026/40701]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_健康与遗传心理学研究室
通讯作者Yanzhi, Bi; Li, Hu
作者单位1.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
2.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
推荐引用方式
GB/T 7714
Huijuan, Zhang,Yanzhi, Bi,Xin, Hou,et al. The role of negative emotions in sex differences in pain sensitivity[J]. Neuroimage,2021,245.
APA Huijuan, Zhang,Yanzhi, Bi,Xin, Hou,Xuejing, Lu,Yiheng, Tu,&Li, Hu.(2021).The role of negative emotions in sex differences in pain sensitivity.Neuroimage,245.
MLA Huijuan, Zhang,et al."The role of negative emotions in sex differences in pain sensitivity".Neuroimage 245(2021).

入库方式: OAI收割

来源:心理研究所

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