Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients
文献类型：期刊论文
| 作者 | Zhang, Yi-Jing1,7; Li, Ying2; Wang, Yong-Ming3; Wang, Shuang-Kun4; Pu, Cheng-Cheng5; Zhou, Shu-Zhe5; Ma, Yan-Tao4; Wang, Yi1,7 ; Lui, Simon S. Y.6; Yu, Xin4
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| 刊名 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
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| 出版日期 | 2021-10-09 |
| 页码 | 11 |
| ISSN号 | 0940-1334 |
| 关键词 | Social brain network Brain hub Network analysis Social function Social network Schizophrenia |
| DOI | 10.1007/s00406-021-01344-x |
| 通讯作者 | Chan, Raymond C. K.(rckchan@psych.ac.cn) |
| 英文摘要 | Hubs in the brain network are the regions with high centrality and are crucial in the network communication and information integration. Patients with schizophrenia (SCZ) exhibit wide range of abnormality in the hub regions and their connected functional connectivity (FC) at the whole-brain network level. Study of the hubs in the brain networks supporting complex social behavior (social brain network, SBN) would contribute to understand the social dysfunction in patients with SCZ. Forty-nine patients with SCZ and 27 healthy controls (HC) were recruited to undertake the resting-state magnetic resonance imaging scanning and completed a social network (SN) questionnaire. The resting-state SBN was constructed based on the automatic analysis results from the NeuroSynth. Our results showed that the left temporal lobe was the only hub of SBN, and its connected FCs strength was higher than the remaining FCs in both two groups. SCZ patients showed the lower association between the hub-connected FCs (compared to the FCs not connected to the hub regions) with the real-life SN characteristics. These results were replicated in another independent sample (30 SCZ and 28 HC). These preliminary findings suggested that the hub-connected FCs of SBN in SCZ patients exhibit the abnormality in predicting real-life SN characteristics. |
| 收录类别 | SCI |
| WOS关键词 | RICH-CLUB ORGANIZATION ; AMYGDALA ; SIZE |
| 资助项目 | Beijing Municipal Science and Technology Commission[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | SPRINGER HEIDELBERG |
| WOS记录号 | WOS:000705678800001 |
| 资助机构 | Beijing Municipal Science and Technology Commission ; National Key Research and Development Programme ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40672]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Chan, Raymond C. K. |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Psychiat, Beijing, Peoples R China 3.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, 16 De Crespigny Pk, London SE5 8AF, England 4.Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China 5.Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth,NHC Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi-Jing,Li, Ying,Wang, Yong-Ming,et al. Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2021:11. |
| APA | Zhang, Yi-Jing.,Li, Ying.,Wang, Yong-Ming.,Wang, Shuang-Kun.,Pu, Cheng-Cheng.,...&Chan, Raymond C. K..(2021).Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,11. |
| MLA | Zhang, Yi-Jing,et al."Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021):11. |
入库方式： OAI收割
来源：心理研究所
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