Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia
文献类型：期刊论文
| 作者 | Su, Xiuru5; Qiao, Limin4; Liu, Qing1; Shang, Yujie5; Guan, Xiaoni3; Xiu, Meihong3; Zhang, Xiangyang2
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2021-10-08 |
| 卷号 | 11期号:1页码:7 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-021-99510-7 |
| 通讯作者 | Xiu, Meihong(xiumeihong9797@gmail.com) ; Zhang, Xiangyang(zhangxy9@gmail.com) |
| 英文摘要 | Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naive first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients. |
| 收录类别 | SCI |
| WOS关键词 | NEUROTROPHIC FACTOR ; NEUROCOGNITIVE DEFICITS ; MAJOR DEPRESSION ; HUMAN-MEMORY ; ASSOCIATION ; VOLUME ; EXPRESSION ; HYPOTHESIS ; CLOZAPINE ; VARIANTS |
| 资助项目 | CAS Pioneer Hundred Talents Program |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000705243600077 |
| 出版者 | NATURE PORTFOLIO |
| 资助机构 | CAS Pioneer Hundred Talents Program |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40678]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Xiu, Meihong; Zhang, Xiangyang |
| 作者单位 | 1.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China 4.Lian Yang Community Hlth Serv Ctr, Shanghai, Peoples R China 5.Hebei Prov Vet Hosp, Dept Psychiat, Baoding, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Xiuru,Qiao, Limin,Liu, Qing,et al. Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia[J]. SCIENTIFIC REPORTS,2021,11(1):7. |
| APA | Su, Xiuru.,Qiao, Limin.,Liu, Qing.,Shang, Yujie.,Guan, Xiaoni.,...&Zhang, Xiangyang.(2021).Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.SCIENTIFIC REPORTS,11(1),7. |
| MLA | Su, Xiuru,et al."Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia".SCIENTIFIC REPORTS 11.1(2021):7. |
入库方式： OAI收割
来源：心理研究所
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