Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis
文献类型：期刊论文
| 作者 | Feng, Jingjing1,2; Fan, Siyuan3; Sun, Yinwei1,2; Ren, Haitao3; Guan, Hongzhi3; Wang, Jing1,2
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| 刊名 | FRONTIERS IN IMMUNOLOGY
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| 出版日期 | 2021-10-07 |
| 卷号 | 12页码:12 |
| ISSN号 | 1664-3224 |
| 关键词 | anti-N-methyl-D-aspartate receptor encephalitis anti-leucine-rich glioma-inactivated 1 encephalitis B-cell immune repertoire common clones adaptive immune responses |
| DOI | 10.3389/fimmu.2021.717598 |
| 通讯作者 | Guan, Hongzhi(guanhz@263.net) ; Wang, Jing(wangjing@psych.ac.cn) |
| 英文摘要 | Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) and anti-leucine-rich glioma-inactivated 1 encephalitis (anti-LGI1E) are the two most common types of antibody-mediated autoimmune encephalitis. We performed a comprehensive analysis of the B-cell immune repertoire in patients with anti-NMDARE (n = 7) and anti-LGI1E (n = 10) and healthy controls (n = 4). The results revealed the presence of many common clones between patients with these two types of autoimmune encephalitis, which were mostly class-switched. Additionally, many differences were found among the anti-NMDARE, anti-LGI1E, and healthy control groups, including the diversity of the B-cell immune repertoire and gene usage preference. These findings suggest that the same adaptive immune responses occur in patients with anti-NMDARE and anti-LGI1E, which deserves further exploration. |
| 收录类别 | SCI |
| WOS关键词 | RECEPTOR ENCEPHALITIS ; ANTIBODIES ; DIAGNOSIS |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000709961700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40691]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Guan, Hongzhi; Wang, Jing |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,et al. Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis[J]. FRONTIERS IN IMMUNOLOGY,2021,12:12. |
| APA | Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,Ren, Haitao,Guan, Hongzhi,&Wang, Jing.(2021).Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis.FRONTIERS IN IMMUNOLOGY,12,12. |
| MLA | Feng, Jingjing,et al."Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis".FRONTIERS IN IMMUNOLOGY 12(2021):12. |
入库方式： OAI收割
来源：心理研究所
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