Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease
文献类型：期刊论文
| 作者 | Liu, Wenyue2,3; Wang, Changpeng4; He, Tingting4; Su, Minghong3,5; Lu, Yuan2; Zhang, Guanyu3,5; Munte, Thomas F.6; Jin, Lirong4; Ye, Zheng1,2
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2021-07-21 |
| 卷号 | 41期号:29页码:6304-6313 |
| 关键词 | basal ganglia functional MRI neuromelanin-sensitive MRI Parkinson's disease sequential working memory substantia nigra |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.0242-21.2021 |
| 通讯作者 | Jin, Lirong(jinlr99@163.com) ; Ye, Zheng(yez@ion.ac.cn) |
| 英文摘要 | Maintaining and manipulating sequences online is essential for daily activities such as scheduling a day. In Parkinson's disease (PD), sequential working memory deficits have been associated with altered regional activation and functional connectivity in the basal ganglia. This study demonstrates that the substantia nigra (SN) integrity correlated with basal ganglia function and sequencing perform-ance in 29 patients with PD (17 women) and 29 healthy controls (HCs; 18 women). In neuromelanin-sensitive structural magnetic resonance imaging (MRI), PD patients showed smaller SNs than HCs. In a digitordering task with functional MRI (fMRI), partici-pants either recalled sequential digits in the original order (pure recall) or rearranged the digits and recalled the new sequence (reorder and recall). PD patients performed less accurately than HCs, accompanied by the caudate and pallidal hypoactivation, subthalamic hyperactivation, and weakened functional connectivity between the bilateral SN and all three basal ganglia regions. PD patients with larger SNs tended to exhibit smaller ordering-related accuracy costs (reorder and recall vs pure recall). This effect was fully mediated by the ordering-related caudate activation. Unlike HCs, the ordering-related accuracy cost correlated with the ordering-related caudate activation but not subthalamic activation in PD patients. Moreover, the ordering-related caudate activation correlated with the SN area but not with the daily dose of D-2/3 receptor agonists. In PD patients, the daily dose of D-2/3 receptor agonists correlated with the ordering-related subthalamic activation, which was not related to the accuracy cost. The findings suggest that damage to the SN may lead to sequential working memory deficits in PD patients, mediated by basal ganglia dysfunction. |
| 收录类别 | SCI |
| WOS关键词 | MPTP-TREATED MONKEYS ; DOPAMINERGIC INNERVATION ; SUBTHALAMIC NUCLEUS ; NEURONAL-ACTIVITY ; NORMAL-STATE ; NEUROMELANIN ; RELEVANCE ; VALIDITY ; NETWORK ; LESION |
| 资助项目 | National Natural Science Foundation of China[31961133025] ; National Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; Shanghai Municipal Science and Technology Commission[2018ZR1406500] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000684595300013 |
| 出版者 | SOC NEUROSCIENCE |
| 资助机构 | National Natural Science Foundation of China ; Shanghai Municipal Science and Technology Major Project ; Shanghai Municipal Science and Technology Commission |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40132]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Jin, Lirong; Ye, Zheng |
| 作者单位 | 1.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, Key Lab Primate Neurobiol, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200032, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 6.Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany |
| 推荐引用方式 GB/T 7714 | Liu, Wenyue,Wang, Changpeng,He, Tingting,et al. Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease[J]. JOURNAL OF NEUROSCIENCE,2021,41(29):6304-6313. |
| APA | Liu, Wenyue.,Wang, Changpeng.,He, Tingting.,Su, Minghong.,Lu, Yuan.,...&Ye, Zheng.(2021).Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease.JOURNAL OF NEUROSCIENCE,41(29),6304-6313. |
| MLA | Liu, Wenyue,et al."Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease".JOURNAL OF NEUROSCIENCE 41.29(2021):6304-6313. |
入库方式： OAI收割
来源：心理研究所
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