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Atypicalities in the developmental trajectory of cortico-striatal functional connectivity in autism spectrum disorder

文献类型：期刊论文

作者Ma, Zeng-Hui2; Lu, Bin4,5; Li, Xue2; Mei, Ting2; Guo, Yan-Qing2; Yang, Liu2; Wang, Hui2; Tang, Xin-Zhou2; Ji, Zhao-Zheng2; Liu, Jing-Ran2
刊名AUTISM
出版日期2021-08-31
页码15
ISSN号1362-3613
关键词autism spectrum disorder development intrinsic functional connectivity large-scale network striatum
DOI10.1177/13623613211041904
通讯作者Cao, Qing-Jiu(caoqingjiu@bjmu.edu.cn) ; Yan, Chao-Gan(yancg@psych.ac.cn) ; Liu, Jing(ljyuch@bjmu.edu.cn)
英文摘要The last decades of neuroimaging research has revealed atypical development of intrinsic functional connectivity within and between large-scale cortical networks in autism spectrum disorder, but much remains unknown about cortico-subcortical developmental connectivity atypicalities. This study examined cortico-striatal developmental intrinsic functional connectivity changes in autism spectrum disorder and explored how those changes may be correlated with autistic traits. We studied 49 individuals with autism spectrum disorder and 52 age-, sex-, and head motion-matched typically developing individuals (5-30 years old (14.0 +/- 5.6)) using resting-state functional magnetic resonance imaging. Age-related differences in striatal intrinsic functional connectivity were compared between the two groups by adopting functional network-based parcellations of the striatum as seeds. Relative to typically developing individuals, autism spectrum disorder individuals showed atypical developmental changes in intrinsic functional connectivities between almost all striatal networks and sensorimotor network/default network, with connectivity increasing with age in the autism spectrum disorder group and decreasing or constant in typically developing individuals. Age-related degree centrality and voxel-mirrored homotopic connectivity atypicalities in sensorimotor network/default network and voxel-mirrored homotopic connectivity disruptions in striatal regions were also observed in autism spectrum disorder. Significant correlations were found between cortico-striatal intrinsic functional connectivities and Autism Diagnostic Observation Schedule communication/repetitive and restricted-behavior subscores in autism spectrum disorder. Our results indicated that developmental atypicalities of cortico-striatal intrinsic functional connectivities might contribute to the neuropathology of autism spectrum disorder. Lay abstract Autism spectrum disorder has long been conceptualized as a disorder of "atypical development of functional brain connectivity (which refers to correlations in activity levels of distant brain regions)." However, most of the research has focused on the connectivity between cortical regions, and much remains unknown about the developmental changes of functional connectivity between subcortical and cortical areas in autism spectrum disorder. We used the technique of resting-state functional magnetic resonance imaging to explore the developmental characteristics of intrinsic functional connectivity (functional brain connectivity when people are asked not to do anything) between subcortical and cortical regions in individuals with and without autism spectrum disorder aged 6-30 years. We focused on one important subcortical structure called striatum, which has roles in motor, cognitive, and affective processes. We found that cortico-striatal intrinsic functional connectivities showed opposite developmental trajectories in autism spectrum disorder and typically developing individuals, with connectivity increasing with age in autism spectrum disorder and decreasing or constant in typically developing individuals. We also found significant negative behavioral correlations between those atypical cortico-striatal intrinsic functional connectivities and autistic symptoms, such as social-communication deficits, and restricted/repetitive behaviors and interests. Taken together, this work highlights that the atypical development of cortico-subcortical functional connectivity might be largely involved in the neuropathological mechanisms of autism spectrum disorder.
收录类别SCI
WOS关键词AGE-RELATED-CHANGES ; BASAL GANGLIA ; CORTICOSTRIATAL CONNECTIVITY ; REPETITIVE BEHAVIORS ; NETWORK ; ORGANIZATION ; CHILDREN ; REGISTRATION ; PARALLEL
资助项目National Key R&D Program of China[2017YFC1309900] ; National Natural Science Foundation of China[81571339] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81471382] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Chinese Academy of Sciences[Z161100000216152]
WOS研究方向Psychology
语种英语
出版者SAGE PUBLICATIONS LTD
WOS记录号WOS:000692605100001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/40166]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Cao, Qing-Jiu; Yan, Chao-Gan; Liu, Jing
作者单位1.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
2.Peking Univ, Natl Clin Res Ctr Mental Disorders Peking Univ Si, Peking Univ Sixth Hosp, NHC Key Lab Mental Hlth,Inst Mental Hlth, 51 Huayuan Rd, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Int Big Data Res Ctr Depress IBRCD, Inst Psychol, Beijing, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Zeng-Hui,Lu, Bin,Li, Xue,et al. Atypicalities in the developmental trajectory of cortico-striatal functional connectivity in autism spectrum disorder[J]. AUTISM,2021:15.
APA Ma, Zeng-Hui.,Lu, Bin.,Li, Xue.,Mei, Ting.,Guo, Yan-Qing.,...&Liu, Jing.(2021).Atypicalities in the developmental trajectory of cortico-striatal functional connectivity in autism spectrum disorder.AUTISM,15.
MLA Ma, Zeng-Hui,et al."Atypicalities in the developmental trajectory of cortico-striatal functional connectivity in autism spectrum disorder".AUTISM (2021):15.

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