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Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression

文献类型：期刊论文

作者Li, Hong1,2,4,5; Song, Qiaoyan3; Zhang, Ruya3; Zhou, Youlong3; Kong, Yazhuo1,2
刊名NEURAL PLASTICITY
出版日期2021-10-08
卷号2021页码:10
ISSN号2090-5904
DOI10.1155/2021/7498714
通讯作者Kong, Yazhuo(kongyz@psych.ac.cn)
英文摘要Numerous neuroimaging studies have demonstrated that the brain plasticity is associated with chronic low back pain (cLBP). However, there is a lack of knowledge regarding the underlying mechanisms of thalamic pathways for chronic pain and psychological effects in cLBP caused by lumbar disc herniation (LDH). Combining psychophysics and magnetic resonance imaging (MRI), we investigated the structural and functional brain plasticity in 36 patients with LDH compared with 38 age- and gender-matched healthy controls. We found that (1) LDH patients had increased psychophysical disturbs (i.e., depression and anxiety), and depression (Beck-Depression Inventory, BDI) was found to be an outstanding significant factor to predict chronic pain (short form of the McGill Pain Questionnaire, SF-MPQ); (2) the LDH group showed significantly smaller fractional anisotropy values in the region of posterior corona radiate while gray matter volumes were comparable in both groups; (3) resting state functional connectivity analysis revealed that LDH patients exhibited increased temporal coupling between the thalamus and dorsolateral prefrontal cortex (DLPFC), which further mediate the relationship from chronic pain to depression. Our results emphasized that thalamic pathways underlying prefrontal cortex might play a key role in regulating chronic pain and depression of the pathophysiology of LDH.

收录类别SCI
WOS关键词BRAIN ; DIFFUSION ; ACCURATE ; ROBUST ; REPRESENTATION ; SURFACE
资助项目National Natural Science Foundation of China[81871436] ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000708267800001
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/40694]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Kong, Yazhuo
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Henan Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Pain, Zhengzhou 450008, Peoples R China
4.Shanxi Med Univ, Dept Psychiat, Hosp 1, Clin Med Coll 1, Taiyuan 030000, Peoples R China
5.Shanxi Med Univ, Shanxi Key Lab Artificial Intelligence Assisted D, Hosp 1, Taiyuan 030000, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hong,Song, Qiaoyan,Zhang, Ruya,et al. Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression[J]. NEURAL PLASTICITY,2021,2021:10.
APA Li, Hong,Song, Qiaoyan,Zhang, Ruya,Zhou, Youlong,&Kong, Yazhuo.(2021).Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression.NEURAL PLASTICITY,2021,10.
MLA Li, Hong,et al."Enhanced Temporal Coupling between Thalamus and Dorsolateral Prefrontal Cortex Mediates Chronic Low Back Pain and Depression".NEURAL PLASTICITY 2021(2021):10.

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来源：心理研究所

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