Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China
文献类型:期刊论文
作者 | Ke Deng2; Ji-Hui Yue3; Jian Xu4; Ping-Ping Ma3,4; Xiao Chen5,6; Le Li5,6; Tong-Jian Bai 6 , Qi-Jing Bo7; Qi-Jing Bo8; Jun Cao9; Guan-Mao Chen10 |
刊名 | Bipolar disorders |
出版日期 | 2021 |
通讯作者邮箱 | yuqicheng@126.com (yuqi cheng) |
DOI | 10.1111/BDI.13139 |
英文摘要 | Background: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to be a male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions: We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres. |
源URL | [http://ir.psych.ac.cn/handle/311026/40719] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
作者单位 | 1.Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan 2.Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China. 3.Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China 4.Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 5.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China 6.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China 7.Anhui Medical University, Hefei, Anhui 230022, China 8.Beijing Anding Hospital, Capital Medical University, Beijing 100054, China 9.Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 10.The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China |
推荐引用方式 GB/T 7714 | Ke Deng,Ji-Hui Yue,Jian Xu,et al. Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China[J]. Bipolar disorders,2021. |
APA | Ke Deng.,Ji-Hui Yue.,Jian Xu.,Ping-Ping Ma.,Xiao Chen.,...&Zheng-Hua Hou.(2021).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.Bipolar disorders. |
MLA | Ke Deng,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China".Bipolar disorders (2021). |
入库方式: OAI收割
来源:心理研究所
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