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New Trajectory of Clinical and Biomarker Changes in Sporadic Alzheimer's Disease

文献类型：期刊论文

作者Zhuo, Junjie1,2,3; Zhang, Yuanchao6; Liu, Yong1,4,5; Liu, Bing1,4,5; Zhou, Xiaoqing2; Bartlett, Perry F.2; Jiang, Tianzi1,2,4,5,6
刊名CEREBRAL CORTEX
出版日期2021-07-01
卷号31期号:7页码:3363-3373
关键词beta-amyloid biomarker trajectories hippocampal volume mild cognitive impairment sporadic Alzheimer's disease
ISSN号1047-3211
DOI10.1093/cercor/bhab017
通讯作者Bartlett, Perry F.(p.bartlett@uq.edu.au) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Identifying dynamic changes in biomarkers and clinical profiles is essential for understanding the progression of Alzheimer's disease (AD). The relevant studies have primarily relied on patients with autosomal dominant AD; however, relevant studies in sporadic AD are poorly understood. Here, we analyzed longitudinal data from 665 participants (mean follow-up 4.90 +/- 2.83 years). By aligning normal cognition (CN) baseline with a clinical diagnosis of mild cognitive impairment (MCI) or AD, we studied the progression of AD using a linear mixed model to estimate the clinical and biomarker changes from stable CN to MCI to AD. The results showed that the trajectory of hippocampal volume and fluorodeoxyglucose (FDG) was consistent with the clinical measures in that they did not follow a hypothetical sigmoid curve but rather showed a slow change in the initial stage and accelerated changes in the later stage from MCI conversion to AD. Dramatic hippocampal atrophy and the ADAS13 increase were, respectively, 2.5 and 1 years earlier than the MCI onset. Besides, cognitively normal people with elevated and normal amyloid showed no significant differences in clinical measures, hippocampal volume, or FDG. These results reveal that pre-MCI to pre-AD may be a better time window for future clinical trial design.
WOS关键词MILD COGNITIVE IMPAIRMENT ; AMYLOID-BETA DEPOSITION ; HYPOTHETICAL MODEL ; INDIVIDUALS ; DECLINE ; ASSOCIATION ; NEURODEGENERATION ; PATHOPHYSIOLOGY ; PATHOLOGY ; DEMENTIA
资助项目Natural Science Foundation of China[31 620 103 905] ; Natural Science Foundation of China[81 701 781] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; Guangdong Pearl River Talents Plan[2016ZT06S220] ; International Postdoctoral Exchange Fellowship Program ; Office of China Postdoctoral Council
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000670805500016
出版者OXFORD UNIV PRESS INC
资助机构Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Guangdong Pearl River Talents Plan ; International Postdoctoral Exchange Fellowship Program ; Office of China Postdoctoral Council
源URL[http://ir.ia.ac.cn/handle/173211/45264]  
专题自动化研究所_模式识别国家重点实验室_视频内容安全团队
自动化研究所_脑网络组研究中心
通讯作者Bartlett, Perry F.; Jiang, Tianzi
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
3.Hainan Univ, Sch Biomed Engn, Haikou 570228, Hainan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Inst Automat, Beijing 100190, Peoples R China
6.Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, MOE Key Lab Neuroinformat, Clin Hosp, Chengdu 625014, Peoples R China
推荐引用方式
GB/T 7714		 Zhuo, Junjie,Zhang, Yuanchao,Liu, Yong,et al. New Trajectory of Clinical and Biomarker Changes in Sporadic Alzheimer's Disease[J]. CEREBRAL CORTEX,2021,31(7):3363-3373.
APA Zhuo, Junjie.,Zhang, Yuanchao.,Liu, Yong.,Liu, Bing.,Zhou, Xiaoqing.,...&Jiang, Tianzi.(2021).New Trajectory of Clinical and Biomarker Changes in Sporadic Alzheimer's Disease.CEREBRAL CORTEX,31(7),3363-3373.
MLA Zhuo, Junjie,et al."New Trajectory of Clinical and Biomarker Changes in Sporadic Alzheimer's Disease".CEREBRAL CORTEX 31.7(2021):3363-3373.

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