中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows

文献类型：期刊论文

作者Yang, Junying2,3,7; He, Shuqing1,4,8; Hu, Zhenhua3,6; Zhang, Zeyu3; Cao, Caiguang3,6; Cheng, Zhen1,8; Fang, Chihua2,7; Tian, Jie3,5
刊名NANO TODAY
出版日期2021-06-01
卷号38页码:11
关键词NIR-II IIa IIb windows Fluorescence imaging Brown adipose tissue Multifunctional nanoprobe Rare-earth-doped nanoparticle Excretory capacity
ISSN号1748-0132
DOI10.1016/j.nantod.2021.101120
通讯作者Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu) ; Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要In vivo fluorescence imaging in the near-infrared II window (NIR-II, 1000 & ndash;1700 nm) has great improvements in imaging quality compared with the visible (400 & ndash;700 nm) and the NIR-I (700 & ndash;900 nm) window due to the low autofluorescence and the reduced scattering. To date, a variety of NIR-II fluorophores have been synthesized and applied in vivo imaging and disease diagnosis. Multifunction is believed as one of the developing trends. In this study, we report a liposome-coated lanthanide nanoparticle, named as NPs@Lips, which can emit three-wavelengths fluorescence (1000 & ndash;1100 nm (NIR-II), 1300 & ndash;1350 nm (NIR-IIa), 1500 & ndash;1700 nm (NIR-IIb) simultaneously under an 808 nm laser excitation. The imaging results demonstrated that the images in longer wavelengths provided a higher resolution and enhanced signal-to-noise (S/N) ratio than the ones in shorter wavelengths. Then, the NPs@Lips were studied for in vivo multifunctional biological imaging, including brown adipose tissue imaging, vascular imaging and lymph node localization biopsy. Interestingly, NPs@Lips can accumulate in brown adipose tissue without any targeting molecules, which provided an alternative sensitive and non-radiation method for brown adipose tissue imaging in the field of metabolic disorders. Overall, the NPs@Lips were potential NIR-II probe for multifunctional nanomedicine applications. (c) 2021 Elsevier Ltd. All rights reserved.
WOS关键词FLUOROPHORES ; NANOPROBES ; SYSTEM ; GREEN
资助项目National Natural Science Foundation of China (NSFC)[81627805] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[22004087] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2016YFC0106500] ; NSFC-GD Union Foundation[U1401254] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Shenzhen Science and Technology Innovation Commission[JCYJ20170817094201000] ; Shenzhen Science and Technology Innovation Commission[JCYJ20190809145601651] ; Natural Science Foundation of Top Talent of SZTU[20200202] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515110926] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201604020144] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201704020141] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000670255000002
出版者ELSEVIER SCI LTD
资助机构National Natural Science Foundation of China (NSFC) ; National Key Research and Development Program of China ; NSFC-GD Union Foundation ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Shenzhen Science and Technology Innovation Commission ; Natural Science Foundation of Top Talent of SZTU ; Guangdong Basic and Applied Basic Research Foundation ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project ; Zhuhai High-level Health Personnel Team Project
源URL[http://ir.ia.ac.cn/handle/173211/45249]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Cheng, Zhen; Fang, Chihua; Tian, Jie
作者单位1.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA
2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China
3.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China
4.Shenzhen Technol Univ, Coll Hlth Sci & Environm Engn, Shenzhen 518118, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China
8.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Mol Imaging Program Stanford MIPS, Bio X Program, Stanford, CA 94305 USA
推荐引用方式
GB/T 7714		 Yang, Junying,He, Shuqing,Hu, Zhenhua,et al. In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows[J]. NANO TODAY,2021,38:11.
APA Yang, Junying.,He, Shuqing.,Hu, Zhenhua.,Zhang, Zeyu.,Cao, Caiguang.,...&Tian, Jie.(2021).In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows.NANO TODAY,38,11.
MLA Yang, Junying,et al."In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows".NANO TODAY 38(2021):11.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。