Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings
文献类型：期刊论文
| 作者 | Azari, Feredun1; Kennedy, Gregory1; Bernstein, Elizabeth1; Hadjipanayis, Constantinos2; Vahrmeijer, Alexander L.3; Smith, Barbara L.4; Rosenthal, Eben5; Sumer, Baran6; Tian, Jie7 ; Henderson, Eric R.8
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| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
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| 出版日期 | 2021-05-01 |
| 卷号 | 26期号:5页码:22 |
| 关键词 | intraoperative molecular imaging fluorescence-guided surgery tumor surgery optical biopsy intraoperative visualization molecular imaging |
| ISSN号 | 1083-3668 |
| DOI | 10.1117/1.JBO.26.5.050901 |
| 通讯作者 | Singhal, Sunil(sunil.singhal@pennmedicine.upenn.edu) |
| 英文摘要 | Significance: Surgery is often paramount in the management of many solid organ malignancies because optimal resection is a major factor in disease-specific survival. Cancer surgery has multiple challenges including localizing small lesions, ensuring negative surgical margins around a tumor, adequately staging patients by discriminating positive lymph nodes, and identifying potential synchronous cancers. Intraoperative molecular imaging (IMI) is an emerging potential tool proposed to address these issues. IMI is the process of injecting patients with fluorescenttargeted contrast agents that highlight cancer cells prior to surgery. Over the last 5 to 7 years, enormous progress has been achieved in tracer development, near-infrared camera approvals, and clinical trials. Therefore, a second biennial conference was organized at the University of Pennsylvania to gather surgical oncologists, scientists, and experts to discuss new investigative findings in the field. Our review summarizes the discussions from the conference and highlights findings in various clinical and scientific trials. Aim: Recent advances in IMI were presented, and the importance of each clinical trial for surgical oncology was critically assessed. A major focus was to elaborate on the clinical endpoints that were being utilized in IMI trials to advance the respective surgical subspecialties. Approach: Principal investigators presenting at the Perelman School of Medicine Abramson Cancer Center's second clinical trials update on IMI were selected to discuss their clinical trials and endpoints. Results: Multiple phase III, II, and I trials were discussed during the conference. Since the approval of 5-ALA for commercial use in neurosurgical malignancies, multiple tracers and devices have been developed to address common challenges faced by cancer surgeons across numerous specialties. Discussants also presented tracers that are being developed for delineation of normal anatomic structures that can serve as an adjunct during surgical procedures. Conclusions: IMI is increasingly being recognized as an improvement to standard oncologic surgical resections and will likely advance the art of cancer surgery in the coming years. The endpoints in each individual surgical subspecialty are varied depending on how IMI helps each specialty solve their clinical challenges. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. |
| WOS关键词 | FLUORESCENCE-GUIDED SURGERY ; BREAST-CANCER ; PANITUMUMAB-IRDYE800CW ; RESECTION ; SGM-101 ; FUTURE ; CEA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000657333600001 |
| 出版者 | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS |
| 源URL | [http://ir.ia.ac.cn/handle/173211/45325]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Singhal, Sunil |
| 作者单位 | 1.Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA 2.Icahn Sch Med Mt Sinai, New York, NY USA 3.Leiden Univ, Med Ctr, Leiden, Netherlands 4.Harvard Univ, Sch Med, Boston, MA USA 5.Stanford Univ, Sch Med, Stanford, CA USA 6.Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA 7.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 8.Dartmouth Coll, Geisel Sch Med, Hanover, NH USA 9.Univ Washington, Sch Med, Seattle, WA USA 10.Univ Calif San Diego, Sch Med, San Diego, CA USA |
| 推荐引用方式 GB/T 7714 | Azari, Feredun,Kennedy, Gregory,Bernstein, Elizabeth,et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings[J]. JOURNAL OF BIOMEDICAL OPTICS,2021,26(5):22. |
| APA | Azari, Feredun.,Kennedy, Gregory.,Bernstein, Elizabeth.,Hadjipanayis, Constantinos.,Vahrmeijer, Alexander L..,...&Singhal, Sunil.(2021).Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.JOURNAL OF BIOMEDICAL OPTICS,26(5),22. |
| MLA | Azari, Feredun,et al."Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings".JOURNAL OF BIOMEDICAL OPTICS 26.5(2021):22. |
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