中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

文献类型：期刊论文

作者Jiang, Bing1,2; Jia, Xiaohua3; Ji, Tianjiao4,5; Zhou, Meng2; He, Jiuyang2; Wang, Kun3; Tian, Jie3,6; Yan, Xiyun1,2; Fan, Kelong1,2
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2021-08-31
页码13
ISSN号1674-7305
关键词ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery
DOI10.1007/s11427-021-1976-0
通讯作者Tian, Jie(pe.tian@ia.ac.cn) ; Yan, Xiyun(yanxy@ibp.ac.cn) ; Fan, Kelong(fankelong@ibp.ac.cn)
英文摘要Engineered nanocarriers have been widely developed for tumor theranostics. However, the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major challenge. Here, by using tailor-functionalized human H-ferritin (HFn), we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor tissues. Then, we developed an HFn-doxorubicin (Dox) drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor therapy. The intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation, and the triple-modality imaging techniques, namely, near-infrared fluorescence molecular imaging (NIR-FMI), magnetic resonance imaging (MRI), and photoacoustic imaging (PAI), ensured the accuracy of detection. Further exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage, followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor 1. Thus, the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early stage. IRDye800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.
WOS关键词BLOOD-BRAIN-BARRIER ; HEPATOCELLULAR-CARCINOMA ; H-FERRITIN ; CANCER ; NANOPARTICLES ; TRANSFERRIN ; CELLS ; PERMEABILITY ; DOXORUBICIN ; DIAGNOSIS
资助项目National Natural Science Foundation of China[31900981] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[32000996] ; Strategic Priority Research Program of CAS[XDB29040101] ; CAS Inter-disciplinary Innovation Team[JCTD-2020-08] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SMC013] ; National Key Research and Development Program of China[2017YFA0205501] ; National Key Research and Development Program of China[2017YFA0205200] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019093] ; China Postdoctoral Science Foundation[2020M682358] ; China Postdoctoral Science Special Foundation[2020TQ0280] ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo[Extension-2019-K3005] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02]
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
出版者SCIENCE PRESS
WOS记录号WOS:000693359700004
资助机构National Natural Science Foundation of China ; Strategic Priority Research Program of CAS ; CAS Inter-disciplinary Innovation Team ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Special Foundation ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health
源URL[http://ir.ia.ac.cn/handle/173211/45962]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Yan, Xiyun; Fan, Kelong
作者单位1.Zhengzhou Univ, Nanozyme Med Ctr, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China
2.Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Bing,Jia, Xiaohua,Ji, Tianjiao,et al. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting[J]. SCIENCE CHINA-LIFE SCIENCES,2021:13.
APA Jiang, Bing.,Jia, Xiaohua.,Ji, Tianjiao.,Zhou, Meng.,He, Jiuyang.,...&Fan, Kelong.(2021).Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting.SCIENCE CHINA-LIFE SCIENCES,13.
MLA Jiang, Bing,et al."Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting".SCIENCE CHINA-LIFE SCIENCES (2021):13.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。