Exploring highly reliable substructures in auto-reconstructions of a neuron
文献类型：期刊论文
| 作者 | He,Yishan1,2; Huang,Jiajin1,2; Wu,Gaowei3,4 ; Yang,Jian1,2,3
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| 刊名 | Brain Informatics
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| 出版日期 | 2021-08-24 |
| 卷号 | 8期号:1 |
| 关键词 | Neuronal morphology Reconstruction Local alignment Motif |
| ISSN号 | 2198-4018 |
| DOI | 10.1186/s40708-021-00137-1 |
| 通讯作者 | Yang,Jian(jianyang@bjut.edu.cn) |
| 英文摘要 | AbstractThe digital reconstruction of a neuron is the most direct and effective way to investigate its morphology. Many automatic neuron tracing methods have been proposed, but without manual check it is difficult to know whether a reconstruction or which substructure in a reconstruction is accurate. For a neuron’s reconstructions generated by multiple automatic tracing methods with different principles or models, their common substructures are highly reliable and named individual motifs. In this work, we propose a Vaa3D-based method called Lamotif to explore individual motifs in automatic reconstructions of a neuron. Lamotif utilizes the local alignment algorithm in BlastNeuron to extract local alignment pairs between a specified objective reconstruction and multiple reference reconstructions, and combines these pairs to generate individual motifs on the objective reconstruction. The proposed Lamotif is evaluated on reconstructions of 163 multiple species neurons, which are generated by four state-of-the-art tracing methods. Experimental results show that individual motifs are almost on corresponding gold standard reconstructions and have much higher precision rate than objective reconstructions themselves. Furthermore, an objective reconstruction is mostly quite accurate if its individual motifs have high recall rate. Individual motifs contain common geometry substructures in multiple reconstructions, and can be used to select some accurate substructures from a reconstruction or some accurate reconstructions from automatic reconstruction dataset of different neurons. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S40708-021-00137-1 |
| 出版者 | Springer Berlin Heidelberg |
| 源URL | [http://ir.ia.ac.cn/handle/173211/45795]  |
| 专题 | 精密感知与控制研究中心_人工智能与机器学习 |
| 通讯作者 | Yang,Jian |
| 作者单位 | 1.Beijing University of Technology; Faculty of Information Technology 2.Beijing International Collaboration Base On Brain Informatics and Wisdom Services 3.University of Chinese Academy of Sciences; School of Artificial Intelligence 4.Chinese Academy of Sciences, Haidian District; Institute of Automation |
| 推荐引用方式 GB/T 7714 | He,Yishan,Huang,Jiajin,Wu,Gaowei,et al. Exploring highly reliable substructures in auto-reconstructions of a neuron[J]. Brain Informatics,2021,8(1). |
| APA | He,Yishan,Huang,Jiajin,Wu,Gaowei,&Yang,Jian.(2021).Exploring highly reliable substructures in auto-reconstructions of a neuron.Brain Informatics,8(1). |
| MLA | He,Yishan,et al."Exploring highly reliable substructures in auto-reconstructions of a neuron".Brain Informatics 8.1(2021). |
入库方式： OAI收割
来源：自动化研究所
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