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Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan

文献类型：期刊论文

作者Ma, Liying1,2; Tian, Lixia1; Hu, Tianyu2,3,4; Jiang, Tianzi2,3,4,5,6,7,8; Zuo, Nianming2,3,4,5
刊名CEREBRAL CORTEX
出版日期2021-08-01
卷号31期号:8页码:3925-3938
关键词adult lifespan brain connectivity connection distance functional MRI (fMRI) individual variability (IndVar)
ISSN号1047-3211
DOI10.1093/cercor/bhab059
通讯作者Zuo, Nianming(nmzuo@nlpr.ia.ac.cn)
英文摘要Individual variability exists in both brain function and behavioral performance. However, changes in individual variability in brain functional connectivity and capability across adult development and aging have not yet been clearly examined. Based on resting-state functional magnetic resonance imaging data from a large cohort of participants (543 adults, aged 18-88 years), brain functional connectivity was analyzed to characterize the spatial distribution and differences in individual variability across the adult lifespan. Results showed high individual variability in the association cortex over the adult lifespan, whereas individual variability in the primary cortex was comparably lower in the initial stage but increased with age. Individual variability was also negatively correlated with the strength/number of short-, medium-, and long-range functional connections in the brain, with long-range connections playing a more critical role in increasing global individual variability in the aging brain. More importantly, in regard to specific brain regions, individual variability in the motor cortex was significantly correlated with differences in motor capability. Overall, we identified specific patterns of individual variability in brain functional structure during the adult lifespan and demonstrated that functional variability in the brain can reflect behavioral performance. These findings advance our understanding of the underlying principles of the aging brain across the adult lifespan and suggest how to characterize degenerating behavioral capability using imaging biomarkers.
WOS关键词NORMAL HUMAN CORTEX ; AGE-RELATED-CHANGES ; PREFRONTAL CORTEX ; CYTOARCHITECTONIC DEFINITION ; SEX-DIFFERENCES ; WORKING-MEMORY ; GLOBAL SIGNAL ; AREAS 9 ; NETWORKS ; STATE
资助项目National Natural Science Foundation of China[61971420] ; National Natural Science Foundation of China[31620103905] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518003] ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission[Z161100000216139] ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission[Z171100000117002]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000674446400025
出版者OXFORD UNIV PRESS INC
资助机构National Natural Science Foundation of China ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission
源URL[http://ir.ia.ac.cn/handle/173211/45531]  
专题自动化研究所_脑网络组研究中心
通讯作者Zuo, Nianming
作者单位1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
5.Chinese Inst Brain Res, Beijing 102206, Peoples R China
6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuro Informat, Minist Educ, Chengdu 625014, Peoples R China
8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式
GB/T 7714		 Ma, Liying,Tian, Lixia,Hu, Tianyu,et al. Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan[J]. CEREBRAL CORTEX,2021,31(8):3925-3938.
APA Ma, Liying,Tian, Lixia,Hu, Tianyu,Jiang, Tianzi,&Zuo, Nianming.(2021).Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan.CEREBRAL CORTEX,31(8),3925-3938.
MLA Ma, Liying,et al."Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan".CEREBRAL CORTEX 31.8(2021):3925-3938.

入库方式： OAI收割

来源：自动化研究所

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