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Ferroptosis in liver disease: new insights into disease mechanisms

文献类型：期刊论文

作者Wu, Jing1; Wang, Yi2; Jiang, Rongtao3; Xue, Ran4; Yin, Xuehong1; Wu, Muchen1; Meng, Qinghua1
刊名CELL DEATH DISCOVERY
出版日期2021-10-05
卷号7期号:1页码:9
DOI10.1038/s41420-021-00660-4
通讯作者Wang, Yi(yves.wangy@vip.163.com) ; Meng, Qinghua(meng_qh0805@ccmu.edu.cn)
英文摘要Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel form of iron-dependent cell death, which is morphologically, genetically, and biochemically distinct from other well-known cell death. In recent years, ferroptosis has been quickly gaining attention in the field of liver diseases, as the liver is predisposed to oxidative injury and generally, excessive iron accumulation is a primary characteristic of most major liver diseases. In the current review, we first delineate three cellular defense mechanisms against ferroptosis (GPx4 in the mitochondria and cytosol, FSP1 on plasma membrane, and DHODH in mitochondria), along with four canonical modulators of ferroptosis (system Xc(-), nuclear factor erythroid 2-related factor 2, p53, and GTP cyclohydrolase-1). Next, we review recent progress of ferroptosis studies delineating molecular mechanisms underlying the pathophysiology of several common liver diseases including ischemia/reperfusion-related injury (IRI), nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), hemochromatosis (HH), drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC). Furthermore, we also highlight both challenges and promises that emerged from recent studies that should be addressed and pursued in future investigations before ferroptosis regulation could be adopted as an effective therapeutic target in clinical practice.
WOS关键词GLUTATHIONE-PEROXIDASE 4 ; CELL-DEATH ; HEPATOCELLULAR-CARCINOMA ; REGULATES FERROPTOSIS ; PROMOTES FERROPTOSIS ; INHIBITS FERROPTOSIS ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; CANCER-CELLS ; PATHWAY
资助项目National Science and Technology Major Project of China[2018ZX10302206-003-007] ; National Science and Technology Major Project of China[2017ZX10203202-001-005] ; Municipal Natural Science Foundation of Beijing, China[7192085] ; Capital Health Research and Development of Special[2018-1-3011] ; National Natural Science Foundation of China[8170877]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000703871400003
出版者SPRINGERNATURE
资助机构National Science and Technology Major Project of China ; Municipal Natural Science Foundation of Beijing, China ; Capital Health Research and Development of Special ; National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/45786]  
专题自动化研究所_脑网络组研究中心
通讯作者Wang, Yi; Meng, Qinghua
作者单位1.Capital Med Univ, Beijing You An Hosp, Dept Med Oncol, Beijing 100069, Peoples R China
2.Beijing Inst Lifeom, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Gastrointestinal Oncol, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Jing,Wang, Yi,Jiang, Rongtao,et al. Ferroptosis in liver disease: new insights into disease mechanisms[J]. CELL DEATH DISCOVERY,2021,7(1):9.
APA Wu, Jing.,Wang, Yi.,Jiang, Rongtao.,Xue, Ran.,Yin, Xuehong.,...&Meng, Qinghua.(2021).Ferroptosis in liver disease: new insights into disease mechanisms.CELL DEATH DISCOVERY,7(1),9.
MLA Wu, Jing,et al."Ferroptosis in liver disease: new insights into disease mechanisms".CELL DEATH DISCOVERY 7.1(2021):9.

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来源：自动化研究所

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