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DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing

文献类型：期刊论文

作者Cheng, Weiqiu1,2; Luo, Na3,4; Zhang, Yuyanan1,2; Zhang, Xiao1,2; Tan, Haoyang5,6; Zhang, Dai1,2,7,8; Sui, Jing4,9; Yue, Weihua1,2,8; Yan, Hao1,2
刊名CEREBRAL CORTEX
出版日期2021-10-01
卷号31期号:10页码:4709-4718
关键词cognition DNA methylation spontaneous brain activity superior temporal gyrus urbanicity
ISSN号1047-3211
DOI10.1093/cercor/bhab117
通讯作者Sui, Jing(kittysj@gmail.com) ; Yue, Weihua(dryue@bjmu.edu.cn) ; Yan, Hao(hao_y@bjmu.edu.cn)
英文摘要Urbanicity has been suggested to affect cognition, but the underlying mechanism remains unknown. We examined whether epigenetic modification (DNA methylation, DNAm), and brain white matter fiber integrity (fractional anisotropy, FA) or local spontaneous brain function activity (regional homogeneity, ReHo) play roles in the association between childhood urbanicity and cognition based on 497 healthy Chinese adults. We found significant correlation between childhood urbanicity and better cognitive performance. Multiset canonical correlation analysis (mCCA) identified an intercorrelated DNAm-FA-ReHo triplet, which showed significant pairwise correlations (DNAm-FA: Bonferroni-adjusted P, P-bon=4.99E-03, rho=0.216; DNAm-ReHo: P-bon=4.08E-03, rho=0.239; ReHo-FA: P-bon=1.68E-06, rho=0.328). Causal mediation analysis revealed that 1) ReHo mediated 10.86% childhood urbanicity effects on the speed of processing and 2) childhood urbanicity alters ReHo through DNA methylation in the cadherin and Wnt signaling pathways (mediated effect: 48.55%). The mediation effect of increased ReHo in the superior temporal gyrus underlying urbanicity impact on a better speed of processing was further validated in an independent cohort. Our work suggests a mediation role for ReHo, particularly increased brain activity in the superior temporal gyrus, in the urbanicity-associated speed of processing.
WOS关键词CONSENSUS COGNITIVE BATTERY ; URBANIZATION ; PERFORMANCE ; CEREBELLUM ; ATTENTION ; PATTERNS ; CHILDREN ; HISTORY ; MEMORY ; RISK
资助项目National Key R&D Program of China[2016YFC1307000] ; National Key R&D Program of China[2016YFC1307201] ; Natural Science Foundation of China[81771443] ; Natural Science Foundation of China[81825009] ; Natural Science Foundation of China[31771186] ; Natural Science Foundation of China[81361120395] ; Natural Science Foundation of China[82022035] ; Natural Science Foundation of China[61773380] ; Natural Science Foundation of China[82001450] ; Peking University Clinical Scientist Program - the Fundamental Research Funds for the Central Universities[BMU2019LCKXJ012] ; Chinese Institute for Brain Research at Beijing[2020-NKX-XM-12] ; Postdoctoral Science Foundation[BX20200364]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000695807700021
出版者OXFORD UNIV PRESS INC
资助机构National Key R&D Program of China ; Natural Science Foundation of China ; Peking University Clinical Scientist Program - the Fundamental Research Funds for the Central Universities ; Chinese Institute for Brain Research at Beijing ; Postdoctoral Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/46013]  
专题自动化研究所_脑网络组研究中心
通讯作者Sui, Jing; Yue, Weihua; Yan, Hao
作者单位1.Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Lieber Inst Brain Dev, Baltimore, MD 21205 USA
6.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
7.Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing 100871, Peoples R China
8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
9.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Weiqiu,Luo, Na,Zhang, Yuyanan,et al. DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing[J]. CEREBRAL CORTEX,2021,31(10):4709-4718.
APA Cheng, Weiqiu.,Luo, Na.,Zhang, Yuyanan.,Zhang, Xiao.,Tan, Haoyang.,...&Yan, Hao.(2021).DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.CEREBRAL CORTEX,31(10),4709-4718.
MLA Cheng, Weiqiu,et al."DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing".CEREBRAL CORTEX 31.10(2021):4709-4718.

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