A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis
文献类型：期刊论文
| 作者 | Cheng, Zhanwen; Liang, Xiaoxing; Liang, Shaojun; Yin, Nuoya; Faiola, Francesco |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2020-01 |
| 卷号 | 87页码:194-204 |
| ISSN号 | 1001-0742 |
| 关键词 | Human embryonic stem cells (hESCs) Keratinocytes Ultrafine carbon particles Inflammation Psoriasis Developmental toxicity |
| 英文摘要 | Air pollution has been linked to many health issues, including skin conditions, especially in children. Among all the atmospheric pollutants, ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin, and be absorbed into the bloodstream. Here, we employed a human embryonic stem cell (hESC)-based differentiation system towards keratinocytes, to test the effects of ultrafine carbon particles, which mimic ambient ultrafine particles, at environment related concentrations. We found that 10 ng/mL to 10 mu g/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in hESCs. Moreover, 1 mu g/mL to 10 mu g/mL carbon particle treatments disrupted the keratinocyte differentiation, and up-regulated inflammation- and psoriasis-related genes, such as IL-1 beta, IL-6, CXCL1, CXCL2, CXCL3, CCL20, CXCL8, and S100A7 and S100A9, respectively. Overall, our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles. (c) 2019 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44578]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Cheng, Zhanwen,Liang, Xiaoxing,Liang, Shaojun,et al. A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2020,87:194-204. |
| APA | Cheng, Zhanwen,Liang, Xiaoxing,Liang, Shaojun,Yin, Nuoya,&Faiola, Francesco.(2020).A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis.JOURNAL OF ENVIRONMENTAL SCIENCES,87,194-204. |
| MLA | Cheng, Zhanwen,et al."A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis".JOURNAL OF ENVIRONMENTAL SCIENCES 87(2020):194-204. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。