Ageing alters the physicochemical properties of silver nanoparticles and consequently compromises their acute toxicity in mammals
文献类型：期刊论文
| 作者 | Wang, Zhe; Li, Qingqing; Xu, Lining; Ma, Juan; Wang, Yan; Wei, Bing; Wu, Weidong; Liu, Sijin |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2020-06-15 |
| 卷号 | 196页码:1-11 |
| 关键词 | Silver nanoparticles Ageing process Physicochemical alterations Health impacts |
| ISSN号 | 0147-6513 |
| 英文摘要 | Despite numerous investigations into AgNP-induced toxicity, little has been taken into consideration the potential health impacts of aged AgNPs in comparison to fresh AgNPs. In the current study, we scrutinized the potential effects of aged AgNPs in animals. We first found that AgNPs underwent morphological transformations after natural ageing in aqueous solution upon exposure to air and sunlight for 9 days, as characterized by significant aggregation with increase of particle size approximately by 2 fold. Meanwhile, dissolved Ag ions from aged AgNPs increased by 33% compared to fresh AgNPs. Strikingly, the acute exposure results showed that aged AgNPs induced lower toxicity in mice relative to fresh AgNPs. Aged AgNPs caused milder local inflammation in the peritoneal cavity of mice, as evidenced by 63% reduction of tumor necrosis factor a (TNF-alpha) than that induced by fresh AgNPs. The deposition mass of aged AgNPs in the liver, spleen, lung and kidney was diminished by 69%, 39%, 83% and 40%, respectively, compared to the distribution profiles in response to fresh AgNPs. Whereby, milder splenic hyperemia was observed, and no significant hepatoxicity was found. Additionally, aged AgNPs provoked milder increase of periphery leukocytes and malondialdehyde (MDA) in mice in comparison to fresh AgNPs. Taken together, this study unraveled that the ageing process elicited remarkable alterations to physicochemical properties and toxic effects as well. This study would provide new insights into the potential health impacts of AgNPs under transformation-determined exposure scenarios. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44594]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Zhe,Li, Qingqing,Xu, Lining,et al. Ageing alters the physicochemical properties of silver nanoparticles and consequently compromises their acute toxicity in mammals[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,196:1-11. |
| APA | Wang, Zhe.,Li, Qingqing.,Xu, Lining.,Ma, Juan.,Wang, Yan.,...&Liu, Sijin.(2020).Ageing alters the physicochemical properties of silver nanoparticles and consequently compromises their acute toxicity in mammals.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,196,1-11. |
| MLA | Wang, Zhe,et al."Ageing alters the physicochemical properties of silver nanoparticles and consequently compromises their acute toxicity in mammals".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 196(2020):1-11. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。