An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine
文献类型：期刊论文
| 作者 | Mao, Li; Huang, Chun-Hua; Shao, Jie; Qin, Li; Xu, Dan; Shao, Bo; Zhu, Ben-Zhan |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2020-02-01 |
| 卷号 | 147页码:150-158 |
| 关键词 | Penicillamine Antioxidant-like activity Tetrachlorohydroquinone Tetrachlorosemiquinone radical Redox reaction Autooxidation |
| ISSN号 | 0891-5849 |
| 英文摘要 | Penicillamine has been widely-used clinically as a copper-chelating drug for the treatment of copper-overload in Wilson's disease. In this study, we found that penicillamine provided marked protection against cytotoxicity induced by tetrachlorohydroquinone (TCHQ), a major toxic metabolite of the well-known wood preservative pentachlorophenol, while other classic copper-chelating agents do not. We found, unexpectedly, that both TCHQ autooxidation and tetrachlorosemiquinone radical (TCSQ(center dot-)) formation were remarkably delayed by penicillamine. Further investigation showed that TCSQ(center dot-) was reduced back to TCHQ by penicillamine, with the concurrent formation of its corresponding disulfide. These data demonstrated that the protection by penicillamine against TCHQ-induced toxicity was not due to its classic Cu-chelating property, but rather to its reduction of the reactive TCSQ(center dot-) to the much less-reactive TCHQ. This is the first report of an unexpected antioxidant and redox activity for penicillamine, which might prove highly relevant to its biological activities. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44600]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Mao, Li,Huang, Chun-Hua,Shao, Jie,et al. An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,147:150-158. |
| APA | Mao, Li.,Huang, Chun-Hua.,Shao, Jie.,Qin, Li.,Xu, Dan.,...&Zhu, Ben-Zhan.(2020).An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine.FREE RADICAL BIOLOGY AND MEDICINE,147,150-158. |
| MLA | Mao, Li,et al."An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine".FREE RADICAL BIOLOGY AND MEDICINE 147(2020):150-158. |
入库方式： OAI收割
来源：生态环境研究中心
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