Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms
文献类型：期刊论文
| 作者 | Yin, Jun-Fa ; Li, Ji-Fang-Tong; Li, Xing-Hong; Yang, You-Lin; Qin, Zhan-Fen
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2020-01-15 |
| 卷号 | 700页码:1-13 |
| 关键词 | Dechlorane plus Adipose tissue Serum Lipids |
| ISSN号 | 0048-9697 |
| 英文摘要 | In this study, bioaccumulation and transfer characteristics of dechlorane plus (DP) were examined between human adipose tissue and matched maternal serum, and the possible transfer mechanism between tissues was further discussed. The median level of total DP was 971 pg g(-1) wet weight (ww) and 1.22 ng g(-1) lipid weight (lw) in adipose tissue, respectively, and was 34.7 pg g(-1 )ww and 3.98 ng g(-1) lw for serum, respectively. DP wet levels' positive association with fat contents of five types of human tissues indicated that DP distribution might be related to lipid-driven mechanism. However, the lipid-adjusted adipose-serum partitioning ratios were estimated to be 0.35 for syn-DP and 0.35 for anti-DP, accordingly, which implied that the DP distribution between serum and adipose tissues, was not only regulated by the tissue lipid contents. Both the internal mono-dechlorination of anti-DP, and stereo-selective behavior of DP isomers were not found in DP transfer from blood to adipose tissue. The marginal positive relationship was observed between serum levels and apolipoprotein A concentrations (p = 0.095 for total DP and 0.045 for syn-DP), and neither association was found between serum levels and thyroid hormone concentrations (THs). To our best knowledge, this is the first report about the accumulation relationship of DP between human adipose tissue and blood stream with the corresponding distribution-related mechanism. (C) 2019 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44617]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yin, Jun-Fa,Li, Ji-Fang-Tong,Li, Xing-Hong,et al. Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,700:1-13. |
| APA | Yin, Jun-Fa,Li, Ji-Fang-Tong,Li, Xing-Hong,Yang, You-Lin,&Qin, Zhan-Fen.(2020).Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms.SCIENCE OF THE TOTAL ENVIRONMENT,700,1-13. |
| MLA | Yin, Jun-Fa,et al."Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms".SCIENCE OF THE TOTAL ENVIRONMENT 700(2020):1-13. |
入库方式： OAI收割
来源：生态环境研究中心
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