Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length
文献类型：期刊论文
| 作者 | Liang, Xiaoxing; Yin, Nuoya; Liang, Shengxian; Yang, Renjun; Liu, Shuyu; Lu, Yuanping; Jiang, Linshu; Zhou, Qunfang; Jiang, Guibin ; Faiola, Francesco
|
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2020-01 |
| 卷号 | 135页码:1-17 |
| 关键词 | Bisphenol A (BPA) derivatives Human neural stem cells Human embryonic stem cells Neural toxicity Neurite length |
| ISSN号 | 0278-6915 |
| 英文摘要 | Bisphenol A (BPA) and its derivatives, including bisphenols S (BPS), F (BPF), E (BPE), B (BPB), Z (BPZ), and AF (BPAF), are widely used in consumer products. Moreover, they are typically detected in the environment, food, and humans. Previous studies have linked BPA to several health risks, but it is still unclear whether BPA replacements are safe. In this study, we developed an in vitro model based on human embryonic stem cells (hESCs) to explore the potential neural toxicity of these compounds. We observed that the bisphenols affected the viability of hESCs and hESC-derived neural stem cells (NSCs) at high concentrations, with BPS being the least cytotoxic and BPAF the strongest cytotoxic compound. At human-relevant concentrations, the bisphenols did not significantly interfere with gene expression and protein levels during hESC differentiation into the neural epithelium, as well as during specification of neuron-like cells from NSCs. Nevertheless, monitoring of cell morphology changes indicated that exposure to BPA and its derivatives impaired neurite length in neuron-like cells. Thus, our findings provide insights into the molecular mechanisms of bisphenol-dependent neurotoxicity at low nanomolar levels and support the view that BPA substitutes may not be sufficiently safe for widespread use as industrial chemicals. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44624]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liang, Xiaoxing,Yin, Nuoya,Liang, Shengxian,et al. Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length[J]. FOOD AND CHEMICAL TOXICOLOGY,2020,135:1-17. |
| APA | Liang, Xiaoxing.,Yin, Nuoya.,Liang, Shengxian.,Yang, Renjun.,Liu, Shuyu.,...&Faiola, Francesco.(2020).Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length.FOOD AND CHEMICAL TOXICOLOGY,135,1-17. |
| MLA | Liang, Xiaoxing,et al."Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length".FOOD AND CHEMICAL TOXICOLOGY 135(2020):1-17. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。