Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure
文献类型：期刊论文
| 作者 | Zhang, Jingxu; Zhou, Qunfang; Su, Ruijun; Sun, Zhendong; Zhang, Weifang ; Jin, Xiaoting; Zheng, Yuxin
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2020-06-15 |
| 卷号 | 721页码:1-16 |
| ISSN号 | 0048-9697 |
| 关键词 | PM2.5 Seasonal variation Cardiac function Metabolic remodeling |
| 英文摘要 | Increasing epidemiological evidences have revealed the association between ambient fine particulate matter (PM2.5) pollution and cardiovascular disease's morbidity and mortality. However, how seasonal PM2.5 exposure influence cardiac function and the underlying mechanism converged in energy metabolic remodeling remain to be elucidated. This study focused on seasonal PM2.5-induced cardiac dysfunction and metabolic remodeling, and the toxicity differences of PM2.5 samples from different sampling seasons and different exposure dosages were discussed. The results showed that seasonal haze caused cardiac dysfunctions, including decreases in heart rate (HR) and heart rate variability (HRV), abnormal changes in hemodynamic and echocardiographic parameters. Concurrently, the energy production in myocardial tissues was evidently disturbed. In particular, low dose of PM2.5 exposure notably induced the elevation of beta oxidation (beta-oxidation) and tricarboxylic acid cycle (TCA cycle) as the compensation for the disturbed energy metabolism in animals, whereas high dose of PM2.5 exposure attenuated this process and the glycolysis levels were strikingly promoted, thus causing the reduced energy production and cardiac dysfunction. Comparatively, winter PM2.5 exposure caused more severe cardiac toxicity than did summer haze samples, possibly due to the existence of different components and pollutant levels in seasonal hazes. The findings on seasonal PM2.5 induced cardiac dysfunction and myocardial metabolic remodeling provided new insights into cardiovascular disease risks from haze exposure. (C) 2020 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44627]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Jingxu,Zhou, Qunfang,Su, Ruijun,et al. Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,721:1-16. |
| APA | Zhang, Jingxu.,Zhou, Qunfang.,Su, Ruijun.,Sun, Zhendong.,Zhang, Weifang.,...&Zheng, Yuxin.(2020).Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure.SCIENCE OF THE TOTAL ENVIRONMENT,721,1-16. |
| MLA | Zhang, Jingxu,et al."Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure".SCIENCE OF THE TOTAL ENVIRONMENT 721(2020):1-16. |
入库方式： OAI收割
来源：生态环境研究中心
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