Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis
文献类型：期刊论文
| 作者 | Han, Xiao; Liu, Hanchen; Zhang, Zezhong; Yang, Wenlan; Wu, Chunyan; Liu, Xueying; Zhang, Fang; Sun, Baofa; Zhao, Yongliang; Jiang, Guibin
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| 刊名 | GENOMICS PROTEOMICS & BIOINFORMATICS
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| 出版日期 | 2020-02 |
| 卷号 | 18期号:1页码:41-51 |
| 关键词 | PM2.5 exposure mRNA m(5)C Pulmonary fibrosis Inflammation Immune response |
| ISSN号 | 1672-0229 |
| 英文摘要 | Exposure of airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 Am (PM2.5) is epidemiologically associated with lung dysfunction and respiratory symptoms, including pulmonary fibrosis. However, whether epigenetic mechanisms are involved in PM2.5-induced pulmonary fibrosis is currently poorly understood. Herein, using a PM2.5-induced pulmonary fibrosis mouse model, we found that PM2.5 exposure leads to aberrant mRNA 5-methylcytosine (m(5)C) gain and loss in fibrotic lung tissues. Moreover, we showed the m(5)C-mediated regulatory map of gene functions in pulmonary fibrosis after PM2.5 exposure. Several genes act as m(5)C gain-upregulated factors, probably critical for the development of PM2.5-induced fibrosis in mouse lungs. These genes, including Lcn2, Mmp9, Chi3l1, Adipoq, Atp5j2, Atp5l, Atpif1, Ndufb6, Fgr, Slc11a1, and Tyrobp, are highly related to oxidative stress response, inflammatory responses, and immune system processes. Our study illustrates the first epitranscrip-tomic RNA m(5)C profile in PM2.5-induced pulmonary fibrosis and will be valuable in identifying biomarkers for PM2.5 exposure-related lung pathogenesis with translational potential. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44677]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Han, Xiao,Liu, Hanchen,Zhang, Zezhong,et al. Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis[J]. GENOMICS PROTEOMICS & BIOINFORMATICS,2020,18(1):41-51. |
| APA | Han, Xiao.,Liu, Hanchen.,Zhang, Zezhong.,Yang, Wenlan.,Wu, Chunyan.,...&Ding, Wenjun.(2020).Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis.GENOMICS PROTEOMICS & BIOINFORMATICS,18(1),41-51. |
| MLA | Han, Xiao,et al."Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis".GENOMICS PROTEOMICS & BIOINFORMATICS 18.1(2020):41-51. |
入库方式： OAI收割
来源：生态环境研究中心
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