Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity
文献类型：期刊论文
| 作者 | Gao, Ming; Dong, Zheng; Sun, Jinfang; Liu, Wei; Xu, Ming; Li, Changying; Zhu, Pan; Yang, Xingfeng; Shang, Xiaohong; Wu, Yongning |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2020-03 |
| 卷号 | 258页码:1-9 |
| ISSN号 | 0269-7491 |
| 关键词 | Cadmium LncRNA MT1DP Nephrotoxicity Exosomes |
| 英文摘要 | Cadmium (Cd) is a well-characterized toxic heavy metal which could cause severe kidney injury. However, currently the knowledge of Cd toxicity towards kidney is still insufficient. Our previous data has identified that MT1DP (metallothionein 1D pseudogene) could promote Cd-induced detrimental effects on hepatocytes. Herein, we further found that MT1DP was also an important intermediate to aggravate Cd-induced nephrotoxicity. Through analyzing the data of 100 residents from Cd-contaminated area in Southern China, we found that the blood MT1DP levels correlated to the urine Cd content and the extent of nephrotoxicity. Although MT1DP was predominantly induced by hepatocytes in the liver, liver-secreted MT1DP was found to be packaged into extracellular cargoes: exosomes, by which MT1DP was delivered into circulation and thereafter targeted kidney cells. Furthermore, exosome-laden MT1DP worsened Cd-induced nephrotoxicity, as evidenced in both Cd-poisoned individuals and in vitro cells. Moreover, MT1DP was found to reinforce Cd-induced toxicity in kidney cells by indirectly breaking the equilibrium between the pro-apoptotic and anti-apoptotic effects conducted by BAX and Bcl-xL, respectively. Collectively, our data unveiled that hepatocyte-derived MT1DP depends on the delivery of exosomes to wreak considerable havoc in Cd nephrotoxicity. This study offers new insights into the molecular mechanisms of Cd-induced kidney injury. (C) 2019 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44723]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Ming,Dong, Zheng,Sun, Jinfang,et al. Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity[J]. ENVIRONMENTAL POLLUTION,2020,258:1-9. |
| APA | Gao, Ming.,Dong, Zheng.,Sun, Jinfang.,Liu, Wei.,Xu, Ming.,...&Liu, Sijin.(2020).Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity.ENVIRONMENTAL POLLUTION,258,1-9. |
| MLA | Gao, Ming,et al."Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity".ENVIRONMENTAL POLLUTION 258(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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