Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
文献类型：期刊论文
| 作者 | Qi, Yu; Zhang, Tong; Jing, Chuanyong; Liu, Sijin; Zhang, Chengdong; Alvarez, Pedro J. J.; Chen, Wei |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2020-03-09 |
| 卷号 | 11期号:1页码:1-9 |
| ISSN号 | 2041-1723 |
| 英文摘要 | Binding of biomolecules to crystal surfaces is critical for effective biological applications of crystalline nanomaterials. Here, we present the modulation of exposed crystal facets as a feasible approach to enhance specific nanocrystal-biomolecule associations for improving cellular targeting and nanomaterial uptake. We demonstrate that facet-engineering significantly enhances transferrin binding to cadmium chalcogenide nanocrystals and their subsequent delivery into cancer cells, mediated by transferrin receptors, in a complex biological matrix. Competitive adsorption experiments coupled with theoretical calculations reveal that the (100) facet of cadmoselite and (002) facet of greenockite preferentially bind with transferrin via inner-sphere thiol complexation. Molecular dynamics simulation infers that facet-dependent transferrin binding is also induced by the differential affinity of crystal facets to water molecules in the first solvation shell, which affects access to exposed facets. Overall, this research underlines the promise of facet engineering to improve the efficacy of crystalline nanomaterials in biological applications. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44742]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Zhang, Tong,Jing, Chuanyong,et al. Nanocrystal facet modulation to enhance transferrin binding and cellular delivery[J]. NATURE COMMUNICATIONS,2020,11(1):1-9. |
| APA | Qi, Yu.,Zhang, Tong.,Jing, Chuanyong.,Liu, Sijin.,Zhang, Chengdong.,...&Chen, Wei.(2020).Nanocrystal facet modulation to enhance transferrin binding and cellular delivery.NATURE COMMUNICATIONS,11(1),1-9. |
| MLA | Qi, Yu,et al."Nanocrystal facet modulation to enhance transferrin binding and cellular delivery".NATURE COMMUNICATIONS 11.1(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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