New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor
文献类型：期刊论文
| 作者 | Xie, Heidi Qunhui; Ma, Yongchao; Fu, Hualing; Xu, Tuan; Luo, Yali; Liu, Yiyun; Chen, Yangsheng; Xu, Li; Xia, Yingjie; Zhao, Bin |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2020-01 |
| 页码 | 1-30 |
| 关键词 | acetylcholinesterase aryl hydrocarbon receptor dioxin dioxin-response element microRNA neurodevelopment |
| ISSN号 | 0022-3042 |
| 英文摘要 | Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Dioxin is an emerging environmental AChE disruptor and is a typical persistent organic pollutant with multiple toxic effects on the nervous system. Growing evidence has shown that there is a significant link between dioxin exposure and neurodegenerative diseases and neurodevelopmental disorders, most of which involve AChE and cholinergic dysfunctions. Therefore, an in-depth understanding of the effects of dioxin on AChE and the related mechanisms of action might help to shed light on the molecular bases of dioxin impacts on the nervous system. In the past decade, the effects of dioxins on AChE have been revealed in cultured cells of different origins and in rodent animal models. Unlike OP and carbamate pesticides, dioxin-induced AChE disturbance is not due to direct inhibition of enzymatic activity; instead, dioxin causes alterations of AChE expression in certain models. As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation. In this mini-review, the effects of dioxin on AChE and the diverse roles of the AhR pathway in AChE regulation are summarized. Additionally, the involvement of AhR in AChE regulation during different neurodevelopmental processes is discussed. These AhR-related findings might also provide new insight into AChE regulation triggered by diverse xenobiotics capable of interacting with AhR. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44748]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xie, Heidi Qunhui,Ma, Yongchao,Fu, Hualing,et al. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor[J]. JOURNAL OF NEUROCHEMISTRY,2020:1-30. |
| APA | Xie, Heidi Qunhui.,Ma, Yongchao.,Fu, Hualing.,Xu, Tuan.,Luo, Yali.,...&Zhao, Bin.(2020).New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor.JOURNAL OF NEUROCHEMISTRY,1-30. |
| MLA | Xie, Heidi Qunhui,et al."New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor".JOURNAL OF NEUROCHEMISTRY (2020):1-30. |
入库方式： OAI收割
来源：生态环境研究中心
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