Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling
文献类型：期刊论文
| 作者 | Hu, Bowen; Yang, Renjun; Cheng, Zhanwen; Liang, Shaojun; Liang, Shengxian; Yin, Nuoya; Faiola, Francesco |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2020-07-05 |
| 卷号 | 393页码:1-9 |
| 关键词 | Silver nanoparticles (AgNPs) Ectoderm Developmental toxicity Stem cell toxicology Cranial placode |
| ISSN号 | 0304-3894 |
| 英文摘要 | Silver nanoparticles (AgNPs) are compounds used in numerous consumer products because of their desirable optical, conducive and antibacterial properties. However, several in vivo and in vitro studies have raised concerns about their potential developmental toxicity. Here, we employed a human embryonic stem cell model to evaluate the potential ectodermal toxicity of AgNPs, at human relevant concentrations. Among the four major ectodermal lineages tested, only cranial placode specification was significantly affected by AgNPs and AgNO3, morphology-wise and in the expression of specific markers, such as SIX3 and PAX6. Mechanistically, we found that the effects of AgNPs on the cranial placode differentiation were probably due to Ag ion leakage and mediated by the FGF signaling. Thus, AgNPs may have the ability to alter the early stages of embryonic development. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44749]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hu, Bowen,Yang, Renjun,Cheng, Zhanwen,et al. Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,393:1-9. |
| APA | Hu, Bowen.,Yang, Renjun.,Cheng, Zhanwen.,Liang, Shaojun.,Liang, Shengxian.,...&Faiola, Francesco.(2020).Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling.JOURNAL OF HAZARDOUS MATERIALS,393,1-9. |
| MLA | Hu, Bowen,et al."Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling".JOURNAL OF HAZARDOUS MATERIALS 393(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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