Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy
文献类型：期刊论文
| 作者 | Tung, Ka-Ki; Chan, Chi-Kong; Zhao, Yao; Chan, Kwan-Kit Jason; Liu, Guorui ; Pavlovic, Nikola M.; Chan, Wan
|
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2020-02-04 |
| 卷号 | 54期号:3页码:1554-1561 |
| ISSN号 | 0013-936X |
| 英文摘要 | Aristolochic acids (AAs) have been known as potent nephrotoxins since the use of AA-containing herbal medicines was linked with a series of sporadic renal fibrotic nephropathy cases, and yet an estimated 100 million people worldwide are still at risk today because of continued use of similar medicines. However, a similar nephropathic condition is endemic in the rural Balkan regions (e.g., Serbian farming villages) and AAs were again found to be the causative agents. In the case of this Balkan endemic nephropathy, AAs were found to have originated from a widespread local weed Aristolochia clematitis L. In this study, we tested the hypothesis that AAs released from decomposition of A. clematitis were also being leached into groundwater, thus polluting the drinking water of local residents. We initiated the study by developing a dispersive solid-phase extraction-based sample preparation method for water samples suspected of AA contamination. The validated method was then coupled with a liquid chromatography-tandem mass spectrometric method to measure AAs in groundwater samples collected from Serbia. Our study revealed for the first time that groundwater in Serbia is extensively contaminated with AA-I, at ng/L levels. Results also showed that AAs are long-lived water contaminants, with no observable concentration changes over a 2-month period of sample storage. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44754]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Tung, Ka-Ki,Chan, Chi-Kong,Zhao, Yao,et al. Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(3):1554-1561. |
| APA | Tung, Ka-Ki.,Chan, Chi-Kong.,Zhao, Yao.,Chan, Kwan-Kit Jason.,Liu, Guorui.,...&Chan, Wan.(2020).Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(3),1554-1561. |
| MLA | Tung, Ka-Ki,et al."Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.3(2020):1554-1561. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。