PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation
文献类型：期刊论文
| 作者 | Long, Yan-Min; Yang, Xue-Zhi; Yang, Qing-Qing; Clermont, Allen C.; Yin, Yong-Guang; Liu, Guang-Liang; Hu, Li-Gang; Liu, Qian; Zhou, Qun-Fang; Liu, Qian S. |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2020-03-15 |
| 卷号 | 386页码:1-16 |
| 关键词 | Fine particulate matter (PM2.5) Vascular permeability Vascular endothelial growth factor receptor Mitogen-activated protein kinase signaling Oxidative stress |
| ISSN号 | 0304-3894 |
| 英文摘要 | Although in-vivo exposure of PM2.5 has been suggested to initiate a disorder on vascular permeability, the effects and related mechanism has not been well defined. In this work, an obvious increase on vascular permeability has been confirmed in vivo by vein injection of PM2.5 into Balb/c mouse. Human umbilical vein vascular endothelial cells and the consisted ex-vivo vascular endothelium were used as model to investigate the effects of PM2.5 on the vascular permeability and the underlying molecular mechanism. Upon PM2.5 exposure, the vascular endothelial growth factor receptor 2 on cell membrane phosphorylates and activates the downstream mitogen-activated protein kinase (MAPK)/ERK signaling. The adherens junction protein VE-cadherin sheds and the intercellular junction opens, damaging the integrity of vascular endothelium via paracellular pathway. Besides, PM2.5 induces the intracellular reactive oxygen species (ROS) production and triggers the oxidative stress including activity decrease of superoxide dismutase, lactate dehydrogenase release and permeability increase of cell membrane. Taken together, the paracellular and transcellular permeability enhancement jointly contributes to the significant increase of endothelium permeability and thus vascular permeability upon PM2.5 exposure. This work provides an insight into molecular mechanism of PM2.5 associated cardiovascular disease and offered a real-time screening method for the health risk of PM2.5. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44777]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Long, Yan-Min,Yang, Xue-Zhi,Yang, Qing-Qing,et al. PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,386:1-16. |
| APA | Long, Yan-Min.,Yang, Xue-Zhi.,Yang, Qing-Qing.,Clermont, Allen C..,Yin, Yong-Guang.,...&Cai, Yong.(2020).PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation.JOURNAL OF HAZARDOUS MATERIALS,386,1-16. |
| MLA | Long, Yan-Min,et al."PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation".JOURNAL OF HAZARDOUS MATERIALS 386(2020):1-16. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。