TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells
文献类型：期刊论文
| 作者 | Shan, Anqi; Leng, Ling; Li, Jing; Luo, Xiu-mei; Fan, Ya-jiao; Yang, Qiaoyun; Xie, Qun-hui; Chen, Yang-sheng; Ni, Chun-sheng; Guo, Li-ming |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2020-11-05 |
| 卷号 | 398页码:1-10 |
| 关键词 | Coexposure Antagonism AhR Migration Invasion |
| ISSN号 | 0304-3894 |
| 英文摘要 | Evidence has shown that the activation of AhR (aryl hydrocarbon receptor) can promote cancer cell metastasis. However, limited studies have been carried out on mixed exposure to endocrine-disrupting chemicals (EDCs), especially in human breast cancer. Therefore, using MCF7 human breast cancer cells, we investigated the effects of coexposure to MEHP (mono 2-ethylhexyl phthalate) and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on cell migration and invasion, as well as the roles of AhR and the MMP/slug pathway. Our data suggest that MEHP or TCDD can induce migration and invasion in MCF7 cells, and the promotion is partly AhR dependent. We also observed that MEHP antagonized TCDD to reduce AhR-mediated CYP1A1 expression. Subsequently, we revealed that MEHP recruited AhR to dioxin response element (DRE) sequences and decreased TCDD-induced AhR-DRE binding in CYP1A1 genes. Overall, MEHP is a potential AHR agonist, capable of decreasing TCDD-induced AhRDRE binding in CYP1A1 genes. The antagonizing effect of coexposure led to the inhibition of the epithelial-mesenchymal transition (EMT) in MCF7 cells. Our study provides new evidence for the potential mechanisms involved in EDCs exposure and their interactions in EMT. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44817]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shan, Anqi,Leng, Ling,Li, Jing,et al. TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,398:1-10. |
| APA | Shan, Anqi.,Leng, Ling.,Li, Jing.,Luo, Xiu-mei.,Fan, Ya-jiao.,...&Tang, Nai-jun.(2020).TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells.JOURNAL OF HAZARDOUS MATERIALS,398,1-10. |
| MLA | Shan, Anqi,et al."TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells".JOURNAL OF HAZARDOUS MATERIALS 398(2020):1-10. |
入库方式： OAI收割
来源：生态环境研究中心
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