The cardinal roles of ferroportin and its partners in controlling cellular iron in and out
文献类型：期刊论文
| 作者 | Yang, Qiuyuan; Liu, Wei; Zhang, Shuping ; Liu, Sijin
|
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 258页码:1-15 |
| 关键词 | Ferroportin Partners RNAs Hepcidin Iron disorders |
| ISSN号 | 0024-3205 |
| 英文摘要 | In mammals, ferroportin (FPN) is the only known iron exporter, and it functions as a water tap in controlling iron absorption from the diet, iron egress from macrophages and other cells. However, its function is implemented not by itself but by a complex with many partners involved. In the current study, we elaborate on the direct partners in calibrating the capability of FPN in exporting iron out of cells, such as ceruloplasmin (CP), hephaestin (HP) and poly(rC)-binding protein 2 (PCBP2). We also recapitulate the current understandings of the regulation of FPN concentration at the post-transcriptional level. Considering the importance of FPN in fine-tuning iron homeostasis, a few therapeutic options are pursued to target FPN and its partners in treating iron diseases. Nonetheless, limited knowledge has been obtained on direct and indirect partners of FPN, so that more efforts should be invested including their therapeutic values. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44822]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Qiuyuan,Liu, Wei,Zhang, Shuping,et al. The cardinal roles of ferroportin and its partners in controlling cellular iron in and out[J]. LIFE SCIENCES,2020,258:1-15. |
| APA | Yang, Qiuyuan,Liu, Wei,Zhang, Shuping,&Liu, Sijin.(2020).The cardinal roles of ferroportin and its partners in controlling cellular iron in and out.LIFE SCIENCES,258,1-15. |
| MLA | Yang, Qiuyuan,et al."The cardinal roles of ferroportin and its partners in controlling cellular iron in and out".LIFE SCIENCES 258(2020):1-15. |
入库方式： OAI收割
来源：生态环境研究中心
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