The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation
文献类型：期刊论文
| 作者 | Liu, Shuyu; Yang, Renjun; Yin, Nuoya; Faiola, Francesco |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2020-02 |
| 卷号 | 88页码:187-199 |
| 关键词 | Short-chain perfluorinated compounds Human mesenchymal stem cells (hMSCs) Adipogenesis/osteogenesis Developmental toxicity PFBS/PFBA/PFHxS/PFHxA |
| ISSN号 | 1001-0742 |
| 英文摘要 | Per- and polyfluorinated alkyl substances (PFASs) are commonly used in industrial processes and daily life products. Because they are persistent, they accumulate in the environment, wildlife and humans. Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention. We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids (PFBS, PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell (hMSC) system. Our results demonstrate significant cyto- and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity. Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA. (C) 2019 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44827]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Shuyu,Yang, Renjun,Yin, Nuoya,et al. The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2020,88:187-199. |
| APA | Liu, Shuyu,Yang, Renjun,Yin, Nuoya,&Faiola, Francesco.(2020).The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation.JOURNAL OF ENVIRONMENTAL SCIENCES,88,187-199. |
| MLA | Liu, Shuyu,et al."The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation".JOURNAL OF ENVIRONMENTAL SCIENCES 88(2020):187-199. |
入库方式： OAI收割
来源：生态环境研究中心
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