USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP
文献类型：期刊论文
| 作者 | Gao, Ming; Guo, Guijie; Huang, Jinzhou; Kloeber, Jake A.; Zhao, Fei; Deng, Min; Tu, Xinyi; Kim, Wootae; Zhou, Qin ; Zhang, Chao
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2020-10-23 |
| 卷号 | 11期号:1页码:1-7 |
| ISSN号 | 2041-1723 |
| 英文摘要 | Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational modifications control the activity or expression of CtIP. However, it remains unclear whether and how cells restrain CtIP activity in unstressed cells and activate CtIP when needed. Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52. Furthermore, depletion of USP52 sensitizes cells to PARP inhibition in a CtIP-dependent manner in vitro and in vivo. Collectively, our findings reveal the key role of USP52 and the regulatory complexity of CtIP deubiquitination in DNA repair. C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44855]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Ming,Guo, Guijie,Huang, Jinzhou,et al. USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP[J]. NATURE COMMUNICATIONS,2020,11(1):1-7. |
| APA | Gao, Ming.,Guo, Guijie.,Huang, Jinzhou.,Kloeber, Jake A..,Zhao, Fei.,...&Lou, Zhenkun.(2020).USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.NATURE COMMUNICATIONS,11(1),1-7. |
| MLA | Gao, Ming,et al."USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP".NATURE COMMUNICATIONS 11.1(2020):1-7. |
入库方式： OAI收割
来源：生态环境研究中心
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