Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death
文献类型：期刊论文
| 作者 | Xu, Shujuan; Zheng, Huizhen; Ma, Ronglin; Wu, Di; Pan, Yanxia; Yin, Chunyang; Gao, Meng; Wang, Weili; Li, Wei ; Liu, Sijin
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2020-07-13 |
| 卷号 | 11期号:1页码:1-9 |
| ISSN号 | 2041-1723 |
| 英文摘要 | Sustainable developments of nanotechnology necessitate the exploration of structure-activity relationships (SARs) at nano-bio interfaces. While ferroptosis may contribute in the developments of some severe diseases (e.g., Parkinson's disease, stroke and tumors), the cellular pathways and nano-SARs are rarely explored in diseases elicited by nano-sized ferroptosis inducers. Here we find that WS2 and MoS2 nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation. Notably, nano-SAR analysis of 20 transition metal dichalcogenides (TMDs) disclosures the decisive role of surface vacancy in ferroptosis. We therefore develop methanol and sulfide passivation as safe design approaches for TMD nanosheets. These findings are validated in animal lungs by oropharyngeal aspiration of TMD nanosheets. Overall, our study highlights the key cellular events as well as nano-SARs in TMD-induced ferroptosis, which may facilitate the safe design of nanoproducts. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44857]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Shujuan,Zheng, Huizhen,Ma, Ronglin,et al. Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death[J]. NATURE COMMUNICATIONS,2020,11(1):1-9. |
| APA | Xu, Shujuan.,Zheng, Huizhen.,Ma, Ronglin.,Wu, Di.,Pan, Yanxia.,...&Li, Ruibin.(2020).Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death.NATURE COMMUNICATIONS,11(1),1-9. |
| MLA | Xu, Shujuan,et al."Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death".NATURE COMMUNICATIONS 11.1(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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