Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo
文献类型：期刊论文
| 作者 | Wu, Peng; Song, Ziteng; Li, Ying; Wang, Huimei; Zhang, Han; Bao, Jiahe; Li, Yuhao; Cui, Jianlin; Jin, Da-Qing; Wang, Aijie |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020-11 |
| 卷号 | 104页码:1-11 |
| ISSN号 | 0045-2068 |
| 关键词 | Iridoids Anti-inflammatory potency NO inhibition Zebrafish model Patrinia heterophylla |
| 英文摘要 | Inflammation, especially chronic inflammation, has been found to be closely related to the pathology of many diseases and the discovery of bioactive natural products to inhibit NO production is one of strategies to treat inflammation. In our continuous search for bioactive natural substances as potential anti-inflammatory agents, five new compounds (1-5) were extracted and purified from Patrinia heterophylla. The NMR and MS data analysis, along with electronic circular dichroism (ECD) calculations, led to the identification of these isolates, which were new iridoids. Using cell and zebrafish models, the in vitro and in vivo anti-inflammatory effects were conducted to evaluate the potency of anti-inflammation of these compounds. The preliminary mechanism was explored using molecular docking and Western blotting experiments. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45189]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu, Peng,Song, Ziteng,Li, Ying,et al. Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo[J]. BIOORGANIC CHEMISTRY,2020,104:1-11. |
| APA | Wu, Peng.,Song, Ziteng.,Li, Ying.,Wang, Huimei.,Zhang, Han.,...&Guo, Yuanqiang.(2020).Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo.BIOORGANIC CHEMISTRY,104,1-11. |
| MLA | Wu, Peng,et al."Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo".BIOORGANIC CHEMISTRY 104(2020):1-11. |
入库方式： OAI收割
来源：生态环境研究中心
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