Ammonia stress reduces antibiotic efflux but enriches horizontal gene transfer of antibiotic resistance genes in anaerobic digestion
文献类型：期刊论文
| 作者 | Zhang, Junya ; Buhe, Chulu; Yu, Dawei; Zhong, Hui; Wei, Yuansong
|
| 刊名 | BIORESOURCE TECHNOLOGY
 |
| 出版日期 | 2020-01 |
| 卷号 | 295页码:1-16 |
| 关键词 | Anaerobic digestion Ammonia stress Metagenomics Antibiotic resistance genes Microbial community |
| ISSN号 | 0960-8524 |
| 英文摘要 | The dynamics of antibiotic resistance genes (ARGs) response to ammonia stress were evaluated using metagenomics and quantitative PCR (qPCR) in anaerobic digestion (AD). Ammonia stress reduced ARGs associated with antibiotic efflux, especially the major facilitator superfamily (MFS) of tet(L), due to free ammonia (FA) that changed the proton gradient of efflux system. Nonetheless, ARGs of antibiotic target alteration, especially ermB, were enriched under ammonia stress, which could be attributed to the initiation of the internal enhancer of the transferability of the broad host range plasmid, pAMbeta1. Statistical analysis elucidated the significant changes of ARGs are directly attributed to the mobile genetic elements (MGEs), but the little affected ARGs are mainly determined by the functional microbes reflected by nitrogen cycling genes (NCyc). This study deciphered the profiles of ARGs response to ammonia stress in AD, which indicated the importance of alleviation of ammonia inhibition for the mitigation of ARGs dissemination. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45014]  |
| 专题 | 生态环境研究中心_水污染控制实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Junya,Buhe, Chulu,Yu, Dawei,et al. Ammonia stress reduces antibiotic efflux but enriches horizontal gene transfer of antibiotic resistance genes in anaerobic digestion[J]. BIORESOURCE TECHNOLOGY,2020,295:1-16. |
| APA | Zhang, Junya,Buhe, Chulu,Yu, Dawei,Zhong, Hui,&Wei, Yuansong.(2020).Ammonia stress reduces antibiotic efflux but enriches horizontal gene transfer of antibiotic resistance genes in anaerobic digestion.BIORESOURCE TECHNOLOGY,295,1-16. |
| MLA | Zhang, Junya,et al."Ammonia stress reduces antibiotic efflux but enriches horizontal gene transfer of antibiotic resistance genes in anaerobic digestion".BIORESOURCE TECHNOLOGY 295(2020):1-16. |
入库方式： OAI收割
来源：生态环境研究中心
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