Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model
文献类型：期刊论文
| 作者 | Pang, Shaochen; Gao, Yue; Wang, Fengbang; Wang, Yuanyuan; Cao, Mengxi; Zhang, Wenjuan; Liang, Yong; Song, Maoyong ; Jiang, Guibin
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2020-05-15 |
| 卷号 | 717页码:1-9 |
| ISSN号 | 0048-9697 |
| 关键词 | AgNPs Epithelialization Proliferation Neutrophil Reactive oxygen species |
| 英文摘要 | Dressings coated with silver nanoparticle (AgNP) are widely used in the management of acute and chronic wounds. However, whether AgNP exerts toxicity on wound healing remains ambiguous. To demonstrate the effects of AgNP on wound healing, we precisely quantified the recovery speed of wound by taking advantage of the fin regeneration of zebrafish. This method also enabled assessment of the adverse effect of AgNP on various steps of wound healing in vivo. We revealed that AgNP treatment at the concentration of 2 mu g/ml impaired fin regeneration when exposure was performed at the phases of epithelialization and the beginning of blastema formation. Cell proliferation of regenerative blastema was significantly decreased after AgNP exposure. But the canonical signals including Wingless/Integrated (Wnt), Notch and Fibroblast growth factor (Fgf) which play important roles in cell proliferation during fin regeneration were not modulated at 36 hours post amputation (hpa). Further study showed that AgNP impaired fin regeneration through declining amputation-induced ROS as early as epithelialized phase at 18 hpa, rather than inducing ROS generation. AgNP exposure also promoted recruitment of neutrophils in the early phase of wound healing, which suggests that this event dampened amputation-induced ROS. Overall, this study suggested that application of AgNP-coated dressings should be carefully considered at the beginning stage of wound healing. (c) 2020 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/44892]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 推荐引用方式 GB/T 7714 | Pang, Shaochen,Gao, Yue,Wang, Fengbang,et al. Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,717:1-9. |
| APA | Pang, Shaochen.,Gao, Yue.,Wang, Fengbang.,Wang, Yuanyuan.,Cao, Mengxi.,...&Jiang, Guibin.(2020).Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model.SCIENCE OF THE TOTAL ENVIRONMENT,717,1-9. |
| MLA | Pang, Shaochen,et al."Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model".SCIENCE OF THE TOTAL ENVIRONMENT 717(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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