Co-infection risk assessment of Giardia and Cryptosporidium with HIV considering synergistic effects and age sensitivity using disability-adjusted life years
文献类型：期刊论文
| 作者 | Han, Mingyi ; Xiao, Shumin; An, Wei; Sang, Chenhui; Li, Hongyan; Ma, Jinfeng; Yang, Min
|
| 刊名 | WATER RESEARCH
 |
| 出版日期 | 2020-05-15 |
| 卷号 | 175页码:1-7 |
| 关键词 | Giardia Cryptosporidium Co-infection risk assessment Age sensitivity Synergistic effects Removal rates |
| ISSN号 | 0043-1354 |
| 英文摘要 | Co-infection with multiple pathogens, especially the spread of Giardia and Cryptosporidium in source water among those with immunodeficiency, is common worldwide, which will result in an increase in overall risk. In this study, the quantitative microbial risk assessment model was used to estimate the cumulative risk of co-infection with Giardia and Cryptosporidium promoted by HIV, considering age sensitivity. The sensitivity of population segments with different ages was estimated by the optimization method, based on clinical data of cryptosporidiosis and giardiasis with age structure. The factors of co-infection enhancement were used to quantify HIV synergism with the action of other pathogens. The removal rates of Giardia and Cryptosporidium through water treatment were estimated by a model involving turbidity and particles. The results showed that children (0-4 years) were 17.911-fold more sensitive to infection with Giardia than adults (15-64 years), and that with Cryptosporidium was 10.592-fold. Removal rates of these parasites in water treatment plants in major cities in China were estimated to be 2.03 log(10). Considering the HIV-synergistic and age-susceptibility effects, the cumulative risk of exposure to Giardia or Cryptosporidium was about 38.781 x 10(-6) DALYs (Disability-adjusted life years) per person per year, which was much higher than the reference risk level recommended by the World Health Organization (10(-6) DALYs). The methodology and results of this study will be useful in better evaluating and reducing the burden due to infection of Giardia and/or Cryptosporidium in China and other countries. (C) 2020 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45253]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Han, Mingyi,Xiao, Shumin,An, Wei,et al. Co-infection risk assessment of Giardia and Cryptosporidium with HIV considering synergistic effects and age sensitivity using disability-adjusted life years[J]. WATER RESEARCH,2020,175:1-7. |
| APA | Han, Mingyi.,Xiao, Shumin.,An, Wei.,Sang, Chenhui.,Li, Hongyan.,...&Yang, Min.(2020).Co-infection risk assessment of Giardia and Cryptosporidium with HIV considering synergistic effects and age sensitivity using disability-adjusted life years.WATER RESEARCH,175,1-7. |
| MLA | Han, Mingyi,et al."Co-infection risk assessment of Giardia and Cryptosporidium with HIV considering synergistic effects and age sensitivity using disability-adjusted life years".WATER RESEARCH 175(2020):1-7. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。