Tissue-specific bioaccumulation, metabolism and excretion of tris (2-ethylhexyl) phosphate (TEHP) in rare minnow (Gobiocyprisrarus)
文献类型：期刊论文
| 作者 | Hou, Rui ; Xu, Yiping; Rao, Kaifeng; Feng, Chenglian; Wang, Zijian
|
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2020-06 |
| 卷号 | 261页码:1-9 |
| ISSN号 | 0269-7491 |
| 关键词 | Tris (2-ethylhexyl) phosphate (TEHP) Bioaccumulation Toxicokinetic Metabolite parent concentration factor In vivo metabolism |
| 英文摘要 | Tris (2-ethylhexyl) phosphate (TEHP) is one of the most commonly used organophosphorus flame retardant (OPFR) analogues and is commonly detected in surface water and sediments. Limited information is available about the metabolic pathway or metabolite formation related to TEHP in fish. In this study, rare minnows (Gobiocyprisrarus) were exposed to TEHP in static water for 30 d to investigate the bioaccumulation and metabolite distribution in the fish muscle, liver, kidney, gill, GI-tract, ovary and testis. Based on the estimated k(up,parent) and k(d,parent) values, the bioconcentration factors (BCFparent) of TEHP in fish tissues were calculated in the order of kidney > ovary approximate to liver approximate to testis > gill approximate to GI-tract > muscle; this finding was consistent with the results of our previous study on other alkylsubstituted OPFRs. In addition, this study identified the metabolic profiles of TEHP in the liver. TEHP was oxidatively metabolized by the fish to a dealkylated metabolite (di 2-ethylhexyl phosphate; DEHP) and hydroxylated TEHP (OH-TEHP). OH-TEHP further underwent extensive phase II metabolism to yield glucuronic acid conjugates. DEHP was mainly distributed in rare minnow in the following order: liver > GI-tract > kidney >> other tissues. However, the metabolite showed lower accumulation potential in fish tissues than TEHP, with metabolite parent concentration factors (MPCFs) for DEHP of less than 0.1 in all the investigated tissues. The BCFparent values of TEHP in various fish tissues were only 9.0 x 10(-3)-7.2 x 10(-4) times its estimated tissue-water partition coefficient (Ktissue-water) values based on tissue lipid, protein and water contents, which indicated the significance of biotransformation in reducing the bioaccumulation potential of TEHP in fish. The toxicokinetic data in the present study help in understanding the tissue-specific bioaccumulation and metabolism pathways of TEHP in fish and highlight the importance of toxicology research on TEHP metabolites in aquatic organisms. (C) 2020 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45372]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Hou, Rui,Xu, Yiping,Rao, Kaifeng,et al. Tissue-specific bioaccumulation, metabolism and excretion of tris (2-ethylhexyl) phosphate (TEHP) in rare minnow (Gobiocyprisrarus)[J]. ENVIRONMENTAL POLLUTION,2020,261:1-9. |
| APA | Hou, Rui,Xu, Yiping,Rao, Kaifeng,Feng, Chenglian,&Wang, Zijian.(2020).Tissue-specific bioaccumulation, metabolism and excretion of tris (2-ethylhexyl) phosphate (TEHP) in rare minnow (Gobiocyprisrarus).ENVIRONMENTAL POLLUTION,261,1-9. |
| MLA | Hou, Rui,et al."Tissue-specific bioaccumulation, metabolism and excretion of tris (2-ethylhexyl) phosphate (TEHP) in rare minnow (Gobiocyprisrarus)".ENVIRONMENTAL POLLUTION 261(2020):1-9. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。