Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Hang, Xiaodong2; Liu, Xiaohan2; Hu, Ying1; Jiao, Yilai3; Wu, Lin2 |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2021-07-30 |
| 卷号 | 2021页码:7 |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2021/5529368 |
| 通讯作者 | Wu, Lin(wulin13@163.com) |
| 英文摘要 | The aim of this study was to evaluate the biocompatibility and osteogenic potential of a Zeolite Socony Mobil-5 (ZSM-5) coating on a Ti-24 Nb-4 Zr-7.9 Sn (Ti-2448) surface. ZSM-5-modified Ti-2448 (ZSM-5/Ti-2448) and Ti-2448 (control) groups were employed. The physical and chemical properties of the two types of samples were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption/desorption, and contact angle methods. The surface of the ZSM-5/Ti-2448 was rougher than that of the original Ti-2448, while the contact angle of the ZSM-5/Ti-2448 was smaller than that of Ti-2448. In addition, the ZSM-5/Ti-2448 largely increased the specific surface area and introduced silanol groups. A bone-like apatite layer could be formed on the surface of ZSM-5/Ti-2448 after 14 days of incubation in a simulated body fluid. ZSM-5/Ti-2448 was not cytotoxic. The number and alkaline phosphatase (ALP) activity of osteoblasts on ZSM-5/Ti-2448 were significantly higher than those on Ti-2448 surfaces, obtained in vitro using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide and ALP activity assays. Few inflammatory cells were observed around ZSM-5/Ti-2448 after insertion into the femurs of Japanese white rabbits after 4, 12, and 26 weeks through hematoxylin-eosin staining. The average gray scale of transforming growth factor-beta 1 (TGF-beta 1) on ZSM-5/Ti-2448 peaked earlier than that on Ti-2448, according to immunohistochemical staining. These results indicate that ZSM-5/Ti-2448 has a good biocompatibility and improved early osteogenic potential compared to a noncoated Ti-2448. |
| 资助项目 | National High-Tech Research and Development Program (863 Program) of China[2015AA033702] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 语种 | 英语 |
| 出版者 | HINDAWI LTD |
| WOS记录号 | WOS:000684340400006 |
| 资助机构 | National High-Tech Research and Development Program (863 Program) of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/159337]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wu, Lin |
| 作者单位 | 1.Dalian Stomatol Hosp, Dept Pediat Dent, Dalian, Peoples R China 2.China Med Univ, Liaoning Prov Key Lab Oral Dis, Dept Prosthodont, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China 3.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,et al. Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:7. |
| APA | Hang, Xiaodong,Liu, Xiaohan,Hu, Ying,Jiao, Yilai,&Wu, Lin.(2021).Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo.BIOMED RESEARCH INTERNATIONAL,2021,7. |
| MLA | Hang, Xiaodong,et al."Zeolite Socony Mobil-Five Coating on Ti-24 Nb-4 Zr-7.9 Sn Promotes Biocompatibility and Osteogenesis In Vitro and In Vivo".BIOMED RESEARCH INTERNATIONAL 2021(2021):7. |
入库方式： OAI收割
来源：金属研究所
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