Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation
文献类型：期刊论文
| 作者 | Chen, Shi-ting2; He, Si-yuan2; Wang, Wan-ying3; Jin, Hai-jun4; Lu, Jian1; Zhang, Ye-yuan4 |
| 刊名 | MATERIALS LETTERS
 |
| 出版日期 | 2021-10-15 |
| 卷号 | 301页码:3 |
| 关键词 | Nanoporous gold Dealloying Cell encapsulation Diabetes treatment Biomaterials Porous material |
| ISSN号 | 0167-577X |
| DOI | 10.1016/j.matlet.2021.130224 |
| 通讯作者 | He, Si-yuan(hesiyuan@gmail.com) |
| 英文摘要 | Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation. |
| 资助项目 | National Natural ScienceFoundation of China[52071057] ; National Natural ScienceFoundation of China[11572087] |
| WOS研究方向 | Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000675889300005 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural ScienceFoundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/159812]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | He, Si-yuan |
| 作者单位 | 1.City Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China 2.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China 3.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,et al. Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation[J]. MATERIALS LETTERS,2021,301:3. |
| APA | Chen, Shi-ting,He, Si-yuan,Wang, Wan-ying,Jin, Hai-jun,Lu, Jian,&Zhang, Ye-yuan.(2021).Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation.MATERIALS LETTERS,301,3. |
| MLA | Chen, Shi-ting,et al."Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation".MATERIALS LETTERS 301(2021):3. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。