Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules
文献类型：期刊论文
| 作者 | Li, Na1,2; Cui, Wei1,2; Cong, Peifang3; Tang, Jie5; Guan, Yong4; Huang, Caihao1,2; Liu, Yunen3; Yu, Chengzhong5; Yang, Rui1,2; Zhang, Xing1,2 |
| 刊名 | BIOACTIVE MATERIALS
 |
| 出版日期 | 2021-08-01 |
| 卷号 | 6期号:8页码:2303-2314 |
| 关键词 | Inorganic-organic hybrid pH responsive ACP clusters Cellular degradation Cryo-soft X-ray tomography |
| DOI | 10.1016/j.bioactmat.2021.01.005 |
| 通讯作者 | Zhang, Xing(xingzhang@imr.ac.cn) |
| 英文摘要 | Amorphous calcium phosphate (ACP) has been widely found during bone and tooth biomineralization, but the meta-stability and labile nature limit further biomedical applications. The present study found that the chelation of polyacrylic acid (PAA) molecules with Ca2+ ions in Mg-ACP clusters (similar to 2.1 +/- 0.5 nm) using a biomineralization strategy produced inorganic-organic Mg-ACP/PAA hybrid nanoparticles with better thermal stability. Mg-ACP/PAA hybrid nanoparticles (similar to 24.0 +/- 4.8 nm) were pH-responsive and could be efficiently digested under weak acidic conditions (pH 5.0-5.5). The internalization of assembled Mg-ACP/PAA nanoparticles by MC3T3-E1 cells occurred through endocytosis, indicated by laser scanning confocal microscopy and cryo-soft X-ray tomography. Our results showed that cellular lipid membranes remained intact without pore formation after Mg-ACP/PAA particle penetration. The assembled Mg-ACP/PAA particles could be digested in cell lysosomes within 24 h under weak acidic conditions, thereby indicating the potential to efficiently deliver encapsulated functional molecules. Both the in vitro and in vivo results preliminarily demonstrated good biosafety of the inorganic-organic Mg-ACP/PAA hybrid nanoparticles, which may have potential for biomedical applications. |
| 资助项目 | National Key Research and Development Program of China from Ministry of Science and Technology[2016YFC1100502] ; Key Research Program of Frontier Sciences from Chinese Academy of Sciences (CAS)[QYZDY-SSW-JSC031] ; Key Research and Development Program of Liaoning Province[201703031] ; Shenyang Key R&D and Technology Transfer Program[Z17-7-023] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | KEAI PUBLISHING LTD |
| WOS记录号 | WOS:000648343800007 |
| 资助机构 | National Key Research and Development Program of China from Ministry of Science and Technology ; Key Research Program of Frontier Sciences from Chinese Academy of Sciences (CAS) ; Key Research and Development Program of Liaoning Province ; Shenyang Key R&D and Technology Transfer Program |
| 源URL | [http://ir.imr.ac.cn/handle/321006/160760]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Xing |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 3.Gen Hosp Northern Theater Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China 4.Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230029, Anhui, Peoples R China 5.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Li, Na,Cui, Wei,Cong, Peifang,et al. Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules[J]. BIOACTIVE MATERIALS,2021,6(8):2303-2314. |
| APA | Li, Na.,Cui, Wei.,Cong, Peifang.,Tang, Jie.,Guan, Yong.,...&Zhang, Xing.(2021).Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules.BIOACTIVE MATERIALS,6(8),2303-2314. |
| MLA | Li, Na,et al."Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules".BIOACTIVE MATERIALS 6.8(2021):2303-2314. |
入库方式： OAI收割
来源：金属研究所
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