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One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing

文献类型：期刊论文

作者Wan, Peng1,2; Wang, Weidan3; Zheng, Lizhen2; Qin, Ling2; Yang, Ke4
刊名JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
出版日期2021-07-10
卷号78页码:92-99
关键词Bisphosphonate Magnesium Coating Electrodeposition Osteoporosis
ISSN号1005-0302
DOI10.1016/j.jmst.2020.10.055
通讯作者Wan, Peng(wanpeng@dgut.edu.cn) ; Qin, Ling(qin@ort.cuhk.edu.hk)
英文摘要Osteoporotic fracture with increase of aging population became an urgent orthopedic problem. Bisphosphonates were widely recommended as effective clinical treatment drugs. Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing. Considering the mild and sustained drug release, a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study. In comparison to conventional soaking method, encapsulated zoledronate coating by one-step electrodeposition method could modulate drug release in first diffusion-controlled and later degradation-controlled manner. The in vitro cell response to zoledronate loaded coating showed enhanced proliferation and osteogenic differentiation of osteoblasts and no significant inhibition on osteoclasts, which could improve bone-forming and decrease bone resorption due to osteoporosis. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目National Natural Science Foundation of China[31500777] ; Research start-up funds of DGUT[GC300501-082] ; Scientific Research Foundation for Young Team of DGUT[TDQN2019005]
WOS研究方向Materials Science ; Metallurgy & Metallurgical Engineering
语种英语
WOS记录号WOS:000652023600009
出版者JOURNAL MATER SCI TECHNOL
资助机构National Natural Science Foundation of China ; Research start-up funds of DGUT ; Scientific Research Foundation for Young Team of DGUT
源URL[http://ir.imr.ac.cn/handle/321006/161499]  
专题金属研究所_中国科学院金属研究所
通讯作者Wan, Peng; Qin, Ling
作者单位1.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Peoples R China
2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China
3.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Wan, Peng,Wang, Weidan,Zheng, Lizhen,et al. One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,78:92-99.
APA Wan, Peng,Wang, Weidan,Zheng, Lizhen,Qin, Ling,&Yang, Ke.(2021).One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,78,92-99.
MLA Wan, Peng,et al."One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 78(2021):92-99.

入库方式： OAI收割

来源：金属研究所

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