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The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration

文献类型：期刊论文

作者Zhang, Nan2,5; Wang, Weidan1,6; Zhang, Xiuzhi6; Nune, Krishna C.4; Zhao, Ying3; Liu, Na5; Misra, R. D. K.4; Yang, Ke1; Tan, Lili1; Yan, Jinglong2
刊名BIOACTIVE MATERIALS
出版日期2021-06-01
卷号6期号:6页码:1765-1776
关键词Magnesium-strontium alloy Segmental defect Degradation behavior Bone regeneration
DOI10.1016/j.bioactmat.2020.11.026
通讯作者Yang, Ke(kyang@imr.ac.cn) ; Tan, Lili(lltan@imr.ac.cn) ; Yan, Jinglong(yjlg4@aliyun.com)
英文摘要Regeneration of long-bone segmental defects remains a challenge for orthopedic surgery. Current treatment options often require several revision procedures to maintain acceptable alignment and achieve osseous healing. A novel hollow tubular system utilizing magnesium-strontium (Mg-Sr) alloy with autogenous morselized bone filled inside to repair segmental defects was developed. To improve the corrosion and biocompatible properties, two coatings, Ca-P and Sr-P coatings, were prepared on surface of the implants. Feasibility of applying these coated implants was systematically evaluated in vitro and in vivo, and simultaneously to have a better understanding on the relationship of degradation and bone regeneration on the healing process. According to the in vitro corrosion study by electrochemical measurements, greater corrosion resistance was obtained for Ca-P coated sample, and attributed to the double-layer protective structure. The cytotoxicity and alkaline phosphatase (ALP) assays demonstrated enhanced bioactivity for Sr-P coated group because of the long-lasting release of beneficial Sr2+. At 12 weeks post-implantation with Mg-Sr alloy porous device, the segmental defects were effectively repaired with respect to both integrity and continuity. In addition, compared with the Ca-P coated implant, the Sr-P coated implant was more proficient at promoting bone formation and mineralization. In summary, the Sr-P coated implants have bioactive properties and exceptional durability, and promote bone healing that is close to the natural rate, implying their potential application for the regeneration of segmental defects.
资助项目Basic Research Project from the Education Office of Heilongjiang Province[2017KYYWF-0738] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01] ; National Natural Science Foundation of China[31500777] ; National Natural Science Foundation of China[81472107]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000630522400020
出版者KEAI PUBLISHING LTD
资助机构Basic Research Project from the Education Office of Heilongjiang Province ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Institute of Metal Research, Chinese Academy of Sciences ; National Natural Science Foundation of China
源URL[http://ir.imr.ac.cn/handle/321006/162153]  
专题金属研究所_中国科学院金属研究所
通讯作者Yang, Ke; Tan, Lili; Yan, Jinglong
作者单位1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Harbin 150081, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
4.Univ Texas El Paso, Dept Met Mat & Biomed Engn, El Paso, TX 79968 USA
5.Qiqihar Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Qiqihar 161000, Peoples R China
6.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Nan,Wang, Weidan,Zhang, Xiuzhi,et al. The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration[J]. BIOACTIVE MATERIALS,2021,6(6):1765-1776.
APA Zhang, Nan.,Wang, Weidan.,Zhang, Xiuzhi.,Nune, Krishna C..,Zhao, Ying.,...&Yan, Jinglong.(2021).The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration.BIOACTIVE MATERIALS,6(6),1765-1776.
MLA Zhang, Nan,et al."The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration".BIOACTIVE MATERIALS 6.6(2021):1765-1776.

入库方式： OAI收割

来源：金属研究所

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