Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges
文献类型：期刊论文
| 作者 | Song, Xiaoqiang1,2; Zhao, Yan2; Liu, Yunen3; Zhang, Wenchang2; Yuan, Xiaoxue1,2; Xu, Lei2; Zhang, Jinsong2 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2021-12-01 |
| 卷号 | 273页码:10 |
| ISSN号 | 0144-8617 |
| 关键词 | Chitin Homogeneous deacetylation Sponge Degree of deacetylation Femoral artery hemostasis |
| DOI | 10.1016/j.carbpol.2021.118615 |
| 通讯作者 | Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jszhang@imr.ac.cn) |
| 英文摘要 | Chitin/chitosan hemostatic materials have long been studied for uncontrolled hemorrhage, an urgent clinical problem due to severe blood-vessel damage or hemophilia. As one of the basic structural parameters of chitin, the degree of deacetylation (DD) significantly affects the material's physical, chemical, as well as biological properties. In this study, partially deacetylated chitins with a wide range of DD (23-81%) were prepared by homogeneous deacetylation, and sponges with these various chitins were fabricated by freeze-drying to study the effects of DD on their hemostatic properties. Among all sponge samples, the chitosan sponge with a DD of 48% showed the highest water absorption, whole blood adsorption, RBC adsorption rate, and the best hemostatic performance in an uncontrolled bleeding model of the rat femoral artery, demonstrating that a certain proportion of acetyl amino and amino groups could also activate the coagulation system and promote the adhesion of platelet and erythrocyte. |
| 资助项目 | National Key Research and Devel-opment Plan[2016YFB0301502] ; National Natural ScienceFoundation of China[U1608255] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000704379800008 |
| 资助机构 | National Key Research and Devel-opment Plan ; National Natural ScienceFoundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/166543]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhao, Yan; Zhang, Jinsong |
| 作者单位 | 1.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Gen Hosp Northern Theater Command, Dept Emergency Med, Shenyang 110016, PR, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Xiaoqiang,Zhao, Yan,Liu, Yunen,et al. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges[J]. CARBOHYDRATE POLYMERS,2021,273:10. |
| APA | Song, Xiaoqiang.,Zhao, Yan.,Liu, Yunen.,Zhang, Wenchang.,Yuan, Xiaoxue.,...&Zhang, Jinsong.(2021).Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges.CARBOHYDRATE POLYMERS,273,10. |
| MLA | Song, Xiaoqiang,et al."Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges".CARBOHYDRATE POLYMERS 273(2021):10. |
入库方式： OAI收割
来源：金属研究所
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