Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction
文献类型：期刊论文
| 作者 | Ullah, Ihsan2,3; Xu, Qian1,2; Jan, Haseen Ullah4; Ren, Ling2; Yang, Ke2 |
| 刊名 | MATERIALS CHEMISTRY AND PHYSICS
 |
| 出版日期 | 2022 |
| 卷号 | 275页码:13 |
| 关键词 | Hydroxyapatite coating Plasma spraying Cytotoxicity Bioactivity Antibacterial |
| ISSN号 | 0254-0584 |
| DOI | 10.1016/j.matchemphys.2021.125219 |
| 通讯作者 | Ren, Ling(lren@imr.ac.cn) |
| 英文摘要 | Recently the use of Sr2+ and Zn2+ ions substituted HA as an excellent biomaterial has been reported. To expand the usage to load-bearing applications, like hip replacement, it has been proposed that the material should be used in the form of a coating on the implant surface. In this work, we prepared Sr2+ and Zn2+ co-substituted HA plasma spray coating at different concentrations on titanium alloy (Ti-6Al-4V). All coatings showed excellent bonding strength with the substrate. The apatite layer formation on the coatings was studied via immersion in SBF. All samples exhibited great capability to induce the apatite layer formation on the coating surface, however, 10Zn5Sr-HA coating inhibited the apatite layer formation. The cell material interaction on the surfaces of the coatings was examined through MC3T3-E1 cell and demonstrated higher biocompatibility, protein adsorption ability, and significantly higher dissolution rate than pure HA coating. However, 10Zn5Sr-HA coating shows cytotoxicity which is confirmed by cell proliferation, cell adhesion, and ALP activity. Besides, some dead cells and poor cellular morphology were also found on the coating surface. The co-substituted HA coating revealed excellent antibacterial ability against bacterial colonization. The addition of Sr2+ to the Zn-HA coating effectively decreased the thermal instability, cytotoxicity, and increased performance as compared to HA coating. From the results, it is indicated that the 5Zn10Sr-HA coating has good bonding strength, bioactivity, biocompatibility, and antibacterial properties. |
| 资助项目 | Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences[174321KYSB20180006] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; National Natural Science Foundation of China[51631009] ; National Natural Science Foundation of China[31870954] ; Liaoning Revitalization Talents Program[XLYC1807069] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000705723800002 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | Key Projects for Foreign Cooperation of Bureau of International Cooperation, Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Liaoning Revitalization Talents Program |
| 源URL | [http://ir.imr.ac.cn/handle/321006/166581]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Ren, Ling |
| 作者单位 | 1.Northeastern Univ, Sch Mat & Engn, Dept Mat Phys & Chem, Key Lab Anisotropy & Texture Mat,Minist Educ, Shenyang 110819, Peoples R China 2.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China 4.Univ Engn & Technol, Peshawar, Khyber Pakhtunk, Pakistan |
| 推荐引用方式 GB/T 7714 | Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,et al. Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction[J]. MATERIALS CHEMISTRY AND PHYSICS,2022,275:13. |
| APA | Ullah, Ihsan,Xu, Qian,Jan, Haseen Ullah,Ren, Ling,&Yang, Ke.(2022).Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction.MATERIALS CHEMISTRY AND PHYSICS,275,13. |
| MLA | Ullah, Ihsan,et al."Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell-material interaction".MATERIALS CHEMISTRY AND PHYSICS 275(2022):13. |
入库方式： OAI收割
来源：金属研究所
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