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DNA-encoded C-H functionality via photoredox-mediated hydrogen atom transformation catalysis

文献类型：期刊论文

作者Shan, Jinming1; Ling, Xing1,2; Liu, JiaXiang1; Wang, Xuan1,2; Lu, Xiaojie1,2
刊名BIOORGANIC & MEDICINAL CHEMISTRY
出版日期2021-07-15
卷号42页码:4
ISSN号0968-0896
关键词Photoredox Hydrogen atom transfer N-Boc saturated heterocycle DNA Encoded Library (DEL)
DOI10.1016/j.bmc.2021.116234
通讯作者Wang, Xuan(wangxuan2@simm.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要We described a mode of catalytic activation that accomplished the alpha-alkylation of N-Boc saturated heterocycles with DNA-linked acrylamide via photoredox-mediated hydrogen atom transfer (HAT) catalysis. This C(sp3)-C (sp3) bond formation reaction tolerated five-, six- and seven-membered cyclic substrates, substantially streamline synthetic efforts to functionalize the alpha-position of heterocycles with native C-H functional handle. This photoredox catalyzed C-H functionalization proceeded in mild DNA-compatible condition, and suited for the construction of DNA-encoded libraries.
WOS关键词CHEMICAL LIBRARIES ; ALKYLATION ; TECHNOLOGY ; DISCOVERY ; SELECTION ; BROMIDES ; SYSTEM ; ROUTES ; DRUGS
资助项目National Natural Science Foundation of China[21877117] ; National Natural Science Foundation of China[91953203] ; National Natural Science Foundation of China[21907103] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Personalized MedicinesMolecular Signaturebased Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040330] ; Personalized MedicinesMolecular Signaturebased Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050405] ; Shanghai Commission of Science and Technology[18431907100]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000674486900006
源URL[http://119.78.100.183/handle/2S10ELR8/296737]  
专题新药研究国家重点实验室
通讯作者Wang, Xuan; Lu, Xiaojie
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhang Jiang Hi Tech Pk, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Shan, Jinming,Ling, Xing,Liu, JiaXiang,et al. DNA-encoded C-H functionality via photoredox-mediated hydrogen atom transformation catalysis[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2021,42:4.
APA Shan, Jinming,Ling, Xing,Liu, JiaXiang,Wang, Xuan,&Lu, Xiaojie.(2021).DNA-encoded C-H functionality via photoredox-mediated hydrogen atom transformation catalysis.BIOORGANIC & MEDICINAL CHEMISTRY,42,4.
MLA Shan, Jinming,et al."DNA-encoded C-H functionality via photoredox-mediated hydrogen atom transformation catalysis".BIOORGANIC & MEDICINAL CHEMISTRY 42(2021):4.

入库方式： OAI收割

来源：上海药物研究所

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