Supramolecular Antagonists Promote Mitochondrial Dysfunction
文献类型：期刊论文
| 作者 | Li, Mingming1; Song, Yanqiu1; Song, Na1; Wu, Guangyao1; Zhou, Hao2; Long, Jiafu2; Zhang, Pengcheng3,4 ; Shi, Linqi1; Yu, Zhilin1
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2021-07-14 |
| 卷号 | 21期号:13页码:5730-5737 |
| 关键词 | Self-Assembly Peptides Drug Delivery Mitochondrion-Targeting Antagonists |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.1c01469 |
| 通讯作者 | Yu, Zhilin(yzh026@nankai.edu.cn) |
| 英文摘要 | Mitochondrion-targeting therapy exhibits great potential in cancer therapy but significantly suffers from limited therapeutic efficiency. Here we report on mitochondrion-targeting supramolecular antagonist-inducing tumor cell death via simultaneously promoting cellular apoptosis and preventing survival. The supramolecular antagonist was created via coassembly of a mitochondrion-targeting pentapeptide with its two derivatives functionalized with a BH3 domain or the drug camptothecin (CPT). While drug CPT released from the antagonist induced cellular apoptosis via decreasing the mitochondrial membrane potential, the BH3 domain prevented cellular survival through facilitating the association between the supramolecular antagonists and antiapoptotic proteins, thereby initiating mitochondrial permeabilization. Both in vitro and in vivo studies confirmed the combinatorial therapeutic effect arising from the BH3 domain and CPT drug within the supramolecular antagonist on cell death and thereby inhibiting tumor growth. Our findings demonstrate an efficient combinatorial mechanism for mitochondrial dysfunction, thus potentially serving as novel organelle-targeting medicines. |
| WOS关键词 | DRUG-DELIVERY ; PEPTIDE ; AFFINITY ; PROBES ; TUMOR |
| 资助项目 | Fundamental Research Funds for the Central Universities (Nankai University)[63213070] ; National Natural Science Foundation of China[21774065] ; National Natural Science Foundation of China[51933006] ; National Natural Science Foundation of China[81972903] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000674354200038 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296763]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Zhilin |
| 作者单位 | 1.Nankai Univ, Coll Chem, Inst Polymer Chem, Key Lab Funct Polymer Mat,Minist Educ,State Key L, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Life Sci, Key Lab Med Chem Biol, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mingming,Song, Yanqiu,Song, Na,et al. Supramolecular Antagonists Promote Mitochondrial Dysfunction[J]. NANO LETTERS,2021,21(13):5730-5737. |
| APA | Li, Mingming.,Song, Yanqiu.,Song, Na.,Wu, Guangyao.,Zhou, Hao.,...&Yu, Zhilin.(2021).Supramolecular Antagonists Promote Mitochondrial Dysfunction.NANO LETTERS,21(13),5730-5737. |
| MLA | Li, Mingming,et al."Supramolecular Antagonists Promote Mitochondrial Dysfunction".NANO LETTERS 21.13(2021):5730-5737. |
入库方式： OAI收割
来源：上海药物研究所
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